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Table 4 Relationship between length of non-steroideal anti-inflammatory drug consumption and breast cancer, according to women’s characteristics

From: Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Population NSAID No consumption Consumption ≤5y Consumption >5y
Controls/cases (n) Controls/cases (n) OR (95 % CI) Controls/cases (n) OR (95 % CI)
All women NSAID (all) 1171/1111 484/445 0.81 (0.67–0.98) 255/180 0.64 (0.50–0.83)
Aspirin 1808/1653 79/70 0.99 (0.67–1.46) 23/13 0.65 (0.31–1.38)
Acetic acid derivatives 1754/1620 113/86 0.75 (0.53–1.06) 43/30 0.75 (0.42–1.32)
Propionic acid derivatives 1351/1232 380/364 0.86 (0.71–1.06) 179/140 0.73 (0.55–0.97)
NSAID others 1862/1697 33/35 1.47 (0.83–2.60) 15/4 -
Premenopausal NSAID (all) 361/415 162/187 0.82 (0.59–1.13) 105/100 0.78 (0.52–1.17)
Aspirin 613/689 12/12 0.72 (0.27–1.95) 3/1 -
Acetic acid derivatives 600/664 21/27 0.68 (0.35–1.34) 7/11 1.02 (0.31–3.32)
Propionic acid derivatives 392/461 146/167 0.85 (0.61–1.19) 90/84 0.81 (0.52–1.25)
NSAID others 618/693 6/8 2.38 (0.63–9.00) 4/1 -
Postmenopausal NSAID (all) 805/696 312/258 0.77 (0.61–0.98) 150/80 0.53 (0.38–0.75)
Aspirin 1181/964 66/58 1.08 (0.70–1.66) 20/12 0.74 (0.33–1.65)
Acetic acid derivatives 1143/956 88/59 0.76 (0.50–1.15) 36/19 0.61 (0.31–1.20)
Propionic acid derivatives 954/781 224/197 0.84 (0.64–1.09) 89/56 0.64 (0.43–0.95)
NSAID others 1229/1004 27/27 1.27 (0.66–2.42) 11/3 -
BMI <25 NSAID (all) 578/537 233/183 0.78 (0.58–1.04) 131/99 0.65 (0.45–0.94)
Aspirin 901/794 32/22 0.84 (0.43–1.63) 9/3 -
Acetic acid derivatives 883/783 44/22 0.40 (0.20–0.77) 15/14 1.16 (0.42–3.15)
Propionic acid derivatives 656/575 191/163 0.89 (0.66–1.21) 95/81 0.80 (0.52–1.22)
NSAID others 919/806 14/11 1.51 (0.56–4.06) 9/2 -
BMI >25 NSAID (all) 593/574 251/262 0.84 (0.65–1.08) 124/81 0.61 (0.43–0.86)
Aspirin 907/859 47/48 1.10 (0.68–1.80) 14/10 0.74 (0.30–1.82)
Acetic acid derivatives 871/837 69/64 0.94 (0.61–1.44) 28/16 0.54 (0.27–1.10)
Propionic acid derivatives 695/657 189/201 0.85 (0.64–1.12) 84/59 0.64 (0.43–0.95)
NSAID others 943/891 19/24 1.44 (0.71–2.95) 6/2 -
  1. OR Odds ratio adjusted for age, recruitment area, education level, tobacco smoking history, BMI family history of breast cancer, number of deliveries, age at first delivery, menarche age, and menopausal status. CI confidence interval