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Table 3 Relationship between NSAID consumption and breast cancer according to women’s characteristics

From: Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Population NSAID Unexposed controls/cases (n) Exposed controls/Cases (n) OR (95 % CI) p
All women NSAID (all) 1170/1111 739/625 0.76 (0.64–0.89) 0.001
Aspirin 1807/1653 102/83 0.91 (0.64–1.29) 0.60
Acetic acid derivatives 1753/1620 156/116 0.75 (0.55–1.01) 0.06
Propionic acid derivatives 1350/1232 559/504 0.82 (0.69–0.98) 0.03
cox2 inhibitors 1891/1731 18/5 0.28 (0.09–0.88) 0.03
NSAID others 1861/1697 48/39 1.13 (0.67–1.89) 0.65
Premenopausal NSAID (all) 361/415 267/287 0.80 (0.60–1.07) 0.14
Aspirin 613/689 15/13 0.60 (0.25–1.47) 0.27
Acetic acid derivatives 600/664 28/38 0.75 (0.42–1.36) 0.35
Propionic acid derivatives 392/451 236/251 0.84 (0.62–1.13) 0.24
cox2 inhibitors 626/701 2/1 - -
NSAID others 618/693 10/9 1.26 (0.41–3.9) 0.69
Postmenopausal NSAID (all) 804/696 462/338 0.69 (0.56–0.86) <0.001
Aspirin 1180/964 86/70 0.99 (0.68–1.46) 0.98
Acetic acid derivatives 1142/956 124/78 0.72 (0.50–1.03) 0.07
Propionic acid derivatives 953/781 313/253 0.78 (0.62–0.98) 0.03
cox2 inhibitors 1250/1030 16/4 - -
NSAID others 1228/1004 38/30 1.05 (0.58–1.90) 0.86
BMI <25 NSAID (all) 578/537 364/282 0.73 (0.57–0.94) 0.02
Aspirin 901/794 41/25 0.74 (0.40–1.35) 0.32
Acetic acid derivatives 883/783 59/36 0.54 (0.31–0.93) 0.03
Propionic acid derivatives 656/575 286/244 0.86 (0.66–1.13) 0.27
cox2 inhibitors 932/816 10/3 - -
NSAID others 919/806 23/13 0.98 (0.42–2.31) 0.97
BMI >25 NSAID (all) 592/574 375/343 0.76 (0.60–0.95) 0.02
Aspirin 906/859 61/58 1.01 (0.65–1.56) 0.96
Acetic acid derivatives 870/837 97/80 0.81 (0.56–1.18) 0.27
Propionic acid derivatives 694/657 273/260 0.78 (0.61–1.00) 0.05
cox2 inhibitors 959/915 8/2 - -
NSAID others 942/891 25/26 1.24 (0.64–2.41) 0.52
  1. OR Odds ratio adjusted for age, recruitment area, education level, tobacco smoking history, BMI family history of breast cancer, number of deliveries, age at first delivery, menarche age, and menopausal status. CI confidence interval