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Table 3 Relationship between NSAID consumption and breast cancer according to women’s characteristics

From: Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Population

NSAID

Unexposed controls/cases (n)

Exposed controls/Cases (n)

OR (95 % CI)

p

All women

NSAID (all)

1170/1111

739/625

0.76 (0.64–0.89)

0.001

Aspirin

1807/1653

102/83

0.91 (0.64–1.29)

0.60

Acetic acid derivatives

1753/1620

156/116

0.75 (0.55–1.01)

0.06

Propionic acid derivatives

1350/1232

559/504

0.82 (0.69–0.98)

0.03

cox2 inhibitors

1891/1731

18/5

0.28 (0.09–0.88)

0.03

NSAID others

1861/1697

48/39

1.13 (0.67–1.89)

0.65

Premenopausal

NSAID (all)

361/415

267/287

0.80 (0.60–1.07)

0.14

Aspirin

613/689

15/13

0.60 (0.25–1.47)

0.27

Acetic acid derivatives

600/664

28/38

0.75 (0.42–1.36)

0.35

Propionic acid derivatives

392/451

236/251

0.84 (0.62–1.13)

0.24

cox2 inhibitors

626/701

2/1

-

-

NSAID others

618/693

10/9

1.26 (0.41–3.9)

0.69

Postmenopausal

NSAID (all)

804/696

462/338

0.69 (0.56–0.86)

<0.001

Aspirin

1180/964

86/70

0.99 (0.68–1.46)

0.98

Acetic acid derivatives

1142/956

124/78

0.72 (0.50–1.03)

0.07

Propionic acid derivatives

953/781

313/253

0.78 (0.62–0.98)

0.03

cox2 inhibitors

1250/1030

16/4

-

-

NSAID others

1228/1004

38/30

1.05 (0.58–1.90)

0.86

BMI <25

NSAID (all)

578/537

364/282

0.73 (0.57–0.94)

0.02

Aspirin

901/794

41/25

0.74 (0.40–1.35)

0.32

Acetic acid derivatives

883/783

59/36

0.54 (0.31–0.93)

0.03

Propionic acid derivatives

656/575

286/244

0.86 (0.66–1.13)

0.27

cox2 inhibitors

932/816

10/3

-

-

NSAID others

919/806

23/13

0.98 (0.42–2.31)

0.97

BMI >25

NSAID (all)

592/574

375/343

0.76 (0.60–0.95)

0.02

Aspirin

906/859

61/58

1.01 (0.65–1.56)

0.96

Acetic acid derivatives

870/837

97/80

0.81 (0.56–1.18)

0.27

Propionic acid derivatives

694/657

273/260

0.78 (0.61–1.00)

0.05

cox2 inhibitors

959/915

8/2

-

-

NSAID others

942/891

25/26

1.24 (0.64–2.41)

0.52

  1. OR Odds ratio adjusted for age, recruitment area, education level, tobacco smoking history, BMI family history of breast cancer, number of deliveries, age at first delivery, menarche age, and menopausal status. CI confidence interval
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BMC Cancer

ISSN: 1471-2407

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