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Table 1 Fuhrman grade, tumor stage and VHL mutation type in 346 ccRCC patients

From: Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance

  Fuhrman n (%) Tumor stage (pT) n (%)
VHL status 1 + 2 3 + 4 1 + 2 3 + 4
Nonsense 6 (21.4) 22 (78.6) 15 (53.6) 13 (46.4)
Frame shift 43 (44.8) 53 (55.2) 51 (53.1) 45 (46.9)
Missense 21 (26.9) 57 (73.1) 45 (56.3) 35 (43.8)
In frame 6 (35.3) 11 (64.7) 6 (37.5) 10 (62.5)
Splice site 3 (20) 12 (80) 9 (56.3) 7 (43.8)
Wild-type 37 (33) 75 (67) 52 (47.3) 58 (52.7)
  1. Tumor stage or grade information was not available for 14 patients
  2. Combined Fuhrman grades: 1 + 2 = low grade, 3 + 4 = high grade tumors
  3. Combined tumor stages: 1 + 2 = organ-confined, 3 + 4 = metastatic