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Table 1 Fuhrman grade, tumor stage and VHL mutation type in 346 ccRCC patients

From: Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance

 

Fuhrman n (%)

Tumor stage (pT) n (%)

VHL status

1 + 2

3 + 4

1 + 2

3 + 4

Nonsense

6 (21.4)

22 (78.6)

15 (53.6)

13 (46.4)

Frame shift

43 (44.8)

53 (55.2)

51 (53.1)

45 (46.9)

Missense

21 (26.9)

57 (73.1)

45 (56.3)

35 (43.8)

In frame

6 (35.3)

11 (64.7)

6 (37.5)

10 (62.5)

Splice site

3 (20)

12 (80)

9 (56.3)

7 (43.8)

Wild-type

37 (33)

75 (67)

52 (47.3)

58 (52.7)

  1. Tumor stage or grade information was not available for 14 patients
  2. Combined Fuhrman grades: 1 + 2 = low grade, 3 + 4 = high grade tumors
  3. Combined tumor stages: 1 + 2 = organ-confined, 3 + 4 = metastatic