Table 1 Characteristic of studies included in the meta-analysis
From: Type 2 diabetes mellitus and risk of colorectal adenoma: a meta-analysis of observational studies
Author | Year | Country | Study type | Mean age | Male (%) | Sample size | Category of exposure (N) | Outcome | Adjusted variable | NOS score |
|---|---|---|---|---|---|---|---|---|---|---|
Chiranjeev Dash [13] | 2014 | US | retrospective | 54.6 (8.5) | 0 (0) | 3668 | T2DM (804) | CRA (917) | age, educational status, body mass index (weight (kg)/height (m)2), physical activity, family history of colorectal cancer in a first-degree relative, menopausal status, smoking status, alcohol intake, total energy intake, red meat intake, fruit and vegetable intake, and regular aspirin use | 8 |
Heike Ursula [14] | 2012 | German | prospective | 61.5 | 670 (62) | 1554 | T2DM (166) | Colorectal neoplasia (389) | age and sex | 8 |
Tomomi Marugame [15] | 2002 | Japan | retrospective | 52.4 | 1389 (100) | 1389 | Newly diagnosed T2DM (41) | CRA (560), Proximal adenomas(254), Distal adenomas (306) | hospital, rank in the Self Defense Forces, alcohol use, and cigarette smoking | 7 |
Hongha T Vu [20] | 2014 | USA | retrospective | 46 | 92 (36.8) | 250 | T2DM (125) | CRA (56) | ethnicity, body mass index, smoking, and alcohol use | 7 |
Rodney Eddi [18] | 2012 | USA | retrospective | 71 | 442 (56.4) | 783 | T2DM (89) | Adenomatous polyps (261) | Age, Sex, TG, LDL, HDL, Smoking, Family history of CRC, Aspirin, NSAID, Statins | 7 |
Mehulkumar K. Kanadiya [19] | 2013 | American | retrospective | 60.63(9.20) | 1697 (49) | 3465 | T2DM (405) | CRA (852) | NA | 3 |
Joseph Carl Anderson [35] | 2011 | USA | retrospective | NA | 76 (38.0) | 290 | T2DM (46) | Any Sessile Serrated Adenomas (90) | NA | 7 |
Bouwens, M [36] | 2011 | NA | retrospective | 60 | 863 | 1836 | T2DM | Combined adenoma-serrated phenotype (139) | NA | 5a |
de Kort, S [37] | 2013 | Netherlands | retrospective | NA | NA | 3335 | T2DM (326) | CRA (1112) | age, gender, BMI and other relevant risk factors | 4a |
Jill E. Elwing [38] | 2006 | US | retrospective | 59.2 | 0 (0) | 600 | All diabetics (100) | Any Adenoma (159) | age, race, hypertension, hypercholesterolemia, BMI, and NSAID status | 7 |
Advanced adenoma (46) | ||||||||||
Kazushige Kawai [39] | 2012 | Japan | prospective | 63.1(10.5) | 109 (61.9) | 176 | T2DM (3888) | Polyp (69) | NA | 7 |
Suminori Kono [40] | 1998 | Japan | retrospective | 50–54 | 5193 (100) | 5193 | T2DM (166) | sigmoid colon adenomas (821) | body mass index (wt [kg]/ht [m]2), cigarette smoking, alcohol use, rank of the Self Defense Forces, and hospital. | 7 |
Takasei Nishii [41] | 2001 | Japan | retrospective | 48.4 | 951 (100) | 951 | T2DM (43) | Colon Adenomas(233) | Age- and BMI | 6 |
Sunghwan Suh [42] | 2011 | Korea | retrospective | 55.9 | 2528 (72.1) | 3505 | T2DM (509) | Multiple Adenomatous | sex, age, BMI, TC, HDL, TG, Fasting plasma glucose, HbA1c | 7 |
Polyps (509) | ||||||||||
Thomas R [43] | 2012 | NA | retrospective | 58.4 | 1230 (95) | 1295 | T2DM (350) | Advanced adenoma (243) | NA | 3a |
Wang, JH [44] | 2013 | China | retrospective | NA | NA | 470 | T2DM | CRA(235) | abdominal circumference, daily calories & fat intake, increased diastolic blood pressure, history of hypertension or fatty liver, family history of cancer in digestive system, LDL and hsCRP, while female and daily fiber intake | 6a |
Misciagna, G [16] | 2004 | Italy | retrospective | 57.5 | 154 (64.4) | 239 | Diabetes (34)/ Glucose (mg/100Â ml) | CRA(153) | NA | 8 |