Nomograms to predict survival after colorectal cancer resection without preoperative therapy

BMC Cancer

Table 7 Comparison of nomogram with AJCC staging system

	Nomogram score	7^th AJCC stage	6^th AJCC stage	P
Training cohort, CSS
AIC	172262	174703	174949	/
Log-likelihood	−86130	−87344	−87468	All <0.0001
C-index (95 % CI)	0.816 (0.810–0.822)	0.777 (0.771–0.783)	0.774 (0.768–0.780)	All <0.0001
Training cohort, OS
AIC	250348	255973	256182	/
Log-likelihood	−125173	−127979	−128085	All <0.0001
C-index (95 % CI)	0.777 (0.772–0.782)	0.698 (0.693–0.0.703)	0.696 (0.691–0.701)	All <0.0001
Validation cohort, CSS
AIC	14983	15261	15272	/
Log-likelihood^a	−7490	−7623	−7630	All <0.0001
C-index^b (95 % CI)	0.809 (0.791–0.827)	0.770 (0.752–0.788)	0.768 (0.750–0.786)	All <0.0001
Validation cohort, OS
AIC	21611	22235	22244	/
Log-likelihood^c	−10805	−11110	−11116	All <0.0001
C-index^d (95 % CI)	0.773 (0.757–0.789)	0.699 (0.683–0.715)	0.697 (0.681–0.713)	All <0.0001
Test cohort, CSS
AIC	102103	104057	105039	/
Log-likelihood	−51050	−52021	−52519	All <0.0001
C-index (95 % CI)	0.838 (0.830–0.846)	0.794 (0.786–0.802)	0.786 (0.778–0.794)	All <0.0001
Test cohort, OS
AIC	141606	145343	146456	/
Log-likelihood	−70802	−72664	−73227	All <0.0001
C-index (95 % CI)	0.802 (0.796–0.808)	0.723 (0.717–0.729)	0.715 (0.709–0.721)	All <0.0001

AJCC American joint committee on cancer, AIC akaike information criterion, C-index concordance index, 95 % CI 95 % confident interval
^aThe P value comparing 6^th and 7^th AJCC stage was 0.0003
^bThe P value comparing 6^th and 7^th AJCC stage was 0.5187
^cThe P value comparing 6^th and 7^th AJCC stage was 0.0006
^dThe P value comparing 6^th and 7^th AJCC stage was 0.3709

ISSN: 1471-2407