Skip to main content

Table 3 Multivariate cox regression analysis of training cohort

From: Nomograms to predict survival after colorectal cancer resection without preoperative therapy

 

Cancer-specific survival

Overall survival

Covariates

HR

95 % CI

P

HR

95 % CI

P

Sex (Male vs. Female)

1.142

1.094–1.193

<0.0001

1.246

1.202–1.293

<0.0001

Race (ref, White)

 Black

1.199

1.130–1.273

<0.0001

1.191

1.132–1.254

<0.0001

 Yellow (Chinese, Korean, Japanese)

0.784

0.702–0.875

<0.0001

0.713

0.649–0.784

<0.0001

 Other

1.030

0.935–1.135

0.5449

0.996

0.915–1.083

0.9203

Marital status at diagnosis (ref, Married)

 Divorced

1.175

1.092–1.265

<0.0001

1.214

1.139–1.293

<0.0001

 Single (never married)

1.235

1.161–1.313

<0.0001

1.277

1.211–1.346

<0.0001

 Widowed

1.189

1.118–1.264

<0.0001

1.224

1.165–1.285

<0.0001

 Unknown

1.014

0.886–1.161

0.8424

1.145

1.029–1.275

0.0131

CEA status (Positive vs. negative)

1.589

1.517–1.664

<0.0001

1.486

1.431–1.543

<0.0001

Extent of surgery (ref, Loc/seg resection)

 Subtotal/hemisection

1.067

1.012–1.125

0.0156

1.040

0.995–1.087

0.0824

 Total resection

1.269

1.139–1.414

<0.0001

1.180

1.073–1.297

0.0007

Tumor site (ref, Proximal colon)

 Distal colon

0.910

0.860–0.962

<0.0001

0.918

0.876–0.962

0.0004

 Overlapping lesion of colon

1.090

0.909–1.307

0.3545

1.111

0.952–1.298

0.1824

 Rectum

1.002

0.935–1.074

0.9516

0.981

0.926–1.040

0.5211

Tumor size (ref, ≤ 5 cm)

 >5 cm

1.029

0.984–1.076

0.2050

1.026

0.989–1.066

0.1741

 Unknown

1.141

1.035–1.258

0.0078

1.075

0.991–1.166

0.0810

Histology (ref, Adenocarcinoma)

 Signet ring cell carcinoma

1.409

1.220–1.626

<0.0001

1.380

1.209–1.575

<0.0001

Tumor grade (ref, G1/G2)

 G3/G4

1.278

1.219–1.339

<0.0001

1.184

1.137–1.233

<0.0001

 Unknown

1.143

0.987–1.323

0.0736

1.049

0.927–1.186

0.4501

pT stage (ref, pT1)

 pT2

1.567

1.312–1.872

<0.0001

1.398

1.254–1.558

<0.0001

 pT3

2.949

2.516–3.457

<0.0001

1.796

1.628–1.981

<0.0001

 pT4a

4.429

3.746–5.237

<0.0001

2.508

2.247–2.799

<0.0001

 pT4b

4.760

4.021–5.634

<0.0001

2.746

2.456–3.069

<0.0001

Metastasis (M1 vs. M0)

4.075

3.876–4.284

<0.0001

3.357

3.213–3.508

<0.0001

  1. HR hazard ratio, 95 % CI 95 % confident interval, ref reference category, Loc/seg resection Local/segmental resection, CEA carcinoembryonic antigen