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Table 2 Univariate cox regression analysis of training cohort

From: Nomograms to predict survival after colorectal cancer resection without preoperative therapy

Variables

Cancer-specific survival

Overall survival

HR

95 % CI

P

HR

95 % CI

P

Sex

 Female

ref

  

ref

  

 Male

1.060

1.018–1.104

0.0049

1.055

1.019–1.091

0.0021

Race

 White

ref

  

ref

  

 Black

1.278

1.206–1.354

<0.0001

1.157

1.101–1.216

<0.0001

 Yellow (Chinese, Korean and Japanese)

0.762

0.682–0.850

<0.0001

0.701

0.638–0.770

<0.0001

 Other

0.974

0.884–1.072

0.5850

0.870

0.800–0.946

0.0011

Marital status at diagnosis

 Married (including separated)

ref

  

ref

  

 Divorced

1.171

1.088–1.259

<0.0001

1.175

1.103–1.251

<0.0001

 Single (never married)

1.332

1.255–1.414

<0.0001

1.316

1.250–1.386

<0.0001

 Widowed

1.376

1.305–1.450

<0.0001

1.746

1.675–1.821

<0.0001

 Unknown

1.045

0.914–1.196

0.5175

1.246

1.120–1.387

0.0001

CEA status

 Negative

ref

  

ref

  

 Positive

3.174

3.042–3.313

<0.0001

2.449

2.366–2.535

<0.0001

Tumor site

 Proximal colon

ref

  

ref

  

 Distal colon

0.892

0.850–0.935

<0.0001

0.835

0.803–0.869

<0.0001

 Overlapping lesion of colon

1.382

1.153–1.657

0.0005

1.294

1.108–1.510

0.0011

 Rectum

0.880

0.833–0.931

<0.0001

0.825

0.787–0.865

<0.0001

Tumor size

 ≤ 5 cm

ref

  

ref

  

 > 5 cm

1.429

1.370–1.491

<0.0001

1.316

1.270–1.363

<0.0001

 Unknown

0.821

0.746–0.904

0.0001

0.806

0.745–0.873

<0.0001

Extent of surgery

 Local/segmental resection

ref

  

ref

  

 Subtotal/hemisection

1.161

1.114–1.211

<0.0001

1.181

1.141–1.223

<0.0001

 Total resection

1.527

1.373–1.699

<0.0001

1.388

1.264–1.525

<0.0001

Histology

 Adenocarcinoma

ref

  

ref

  

 Signet ring cell carcinoma

2.648

2.304–3.044

<0.0001

2.180

1.916–2.480

<0.0001

Tumor grade

 G1/G2

ref

  

ref

  

 G3/G4

1.903

1.820–1.989

<0.0001

1.614

1.553–1.678

<0.0001

 Unknown

1.007

0.871–1.164

0.9283

0.942

0.834–1.064

0.3372

pT stage

 pT1

ref

  

ref

  

 pT2

1.854

1.556–2.209

<0.0001

1.662

1.495–1.848

<0.0001

 pT3

6.161

5.285–7.182

<0.0001

3.150

2.871–1.848

<0.0001

 pT4a

13.422

11.43–15.760

<0.0001

5.775

5.21–6.400

<0.0001

 pT4b

17.429

14.844–20.464

<0.0001

7.324

6.607–8.120

<0.0001

Metastasis

 M0

ref

  

ref

  

 M1

7.733

7.414–8.066

<0.0001

4.953

4.773–5.139

<0.0001

  1. HR hazard ratio, 95 % CI 95 % confident interval, ref reference category, CEA carcinoembryonic antigen