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Table 10 Risk stratifications for each AJCC substage in training and test cohorts

From: Nomograms to predict survival after colorectal cancer resection without preoperative therapy

   Training cohort   Test cohort
AJCC stages Cut-off Points Cumulative Survival, 60 months, % HR 95 % CI Pairwise Plog-rank HR 95 % CI Pairwise Plog-rank
Cancer-specific survival
 Stage I
  Low risk group (L) ≤70.0 97.7 ref   L v M < 0.0001 ref   L v M < 0.0205
  Median risk group (M) ≤97.2 94.4 2.44 1.91–3.13 L v H < 0.0001 1.75 1.24–2.45 L v H < 0.0001
  High risk group (H) 97.2+ 88.4 4.73 3.66–6.12 M v H < 0.0001 6.12 4.27–8.77 M v H < 0.0001
 Stage IIA
  Low risk group (L) ≤122.7 93.9 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤149.4 87.7 1.90 1.64–2.19 L v H < 0.0001 2.11 1.4–2.58 L v H < 0.0001
  High risk group (H) 149.4+ 76.2 3.96 3.41–4.61 M v H < 0.0001 4.66 3.80–5.72 M v H < 0.0001
 Stage IIB
  Low risk group (L) ≤151.2 84.4 ref   L v M = 0.0046 ref   L v M = 0.0220
  Median risk group (M) ≤178.4 71.1 1.84 1.28–2.64 L v H < 0.0001 2.09 1.29–3.39 L v H < 0.0001
  High risk group (H) 178.4+ 54.1 3.30 2.22–4.90 M v H < 0.0012 5.27 3.16–8.81 M v H < 0.0001
 Stage IIC
  Low risk group (L) ≤158.0 76.7 ref   L v M = 0.0121 ref   L v M = 0.6571
  Median risk group (M) ≤181.8 62.3 1.64 1.16–2.31 L v H < 0.0001 1.12 0.72–1.74 L v H < 0.0001
  High risk group (H) 181.8+ 45.6 2.79 1.93–2.03 M v H < 0.0020 2.73 1.68–4.42 M v H < 0.0001
 Stage IIIA
  Low risk group (L) ≤88.9 94.8 ref   L v M = 0.0116 ref   L v M < 0.0210
  Median risk group (M) ≤120.2 91.6 2.04 1.39–2.99 L v H < 0.0001 2.51 1.36–4.63 L v H < 0.0001
  High risk group (H) 120.2+ 75.6 6.84 4.57–10.24 M v H < 0.0001 6.54 3.20–13.35 M v H = 0.0015
 Stage IIIB
  Low risk group (L) ≤147.6 85.9 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤180.3 72.1 2.09 1.89–2.32 L v H < 0.0001 2.35 2.04–2.70 L v H < 0.0001
  High risk group (H) 180.3+ 50.1 4.25 3.80–4.76 M v H < 0.0001 5.34 4.55–2.67 M v H < 0.0001
 Stage IIIC
  Low risk group (L) ≤187.2 65.1 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤218.0 41.6 1.99 1.74–2.27 L v H < 0.0001 2.01 1.72–2.36 L v H < 0.0001
  High risk group (H) 218.0+ 24.8 3.49 3.01–4.04 M v H < 0.0001 4.05 3.39–4.84 M v H < 0.0001
 Stage IV
  Low risk group (L) ≤255.6 26.2 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤292.1 12.0 1.56 1.46–1.67 L v H < 0.0001 1.85 1.70–2.01 L v H < 0.0001
  High risk group (H) 292.1+ 4.0 2.78 2.57–3.01 M v H < 0.0001 3.34 3.20–3.70 M v H < 0.0001
Overall survival
 Stage I
  Low risk group (L) ≤55.1 94.6 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤79.9 84.5 2.94 2.58–3.35 L v H < 0.0001 3.10 2.58–3.72 L v H < 0.0001
  High risk group (H) 79.9+ 63.1 9.07 7.90–10.41 M v H < 0.0001 10.70 8.80–13.01 M v H < 0.0001
 Stage IIA
  Low risk group (L) ≤75.9 90.6 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤101.4 77.0 2.66 2.42–2.91 L v H < 0.0001 2.86 2.50–3.28 L v H < 0.0001
  High risk group (H) 101.4+ 49.1 7.38 6.68–8.15 M v H < 0.0001 7.80 6.77–8.97 M v H < 0.0001
 Stage IIB
  Low risk group (L) ≤93.5 80.3 ref   L v M = 0.0007 ref   L v M < 0.0001
  Median risk group (M) ≤120.4 64.7 1.86 1.40–2.45 L v H < 0.0001 3.86 2.60–5.72 L v H < 0.0001
  High risk group (H) 120.4+ 26.8 5.48 4.00–7.49 M v H < 0.0001 8.03 5.27–12.22 M v H < 0.0001
 Stage IIC
  Low risk group (L) ≤96.9 73.6 ref   L v M < 0.0001 ref   L v M = 0.2111
  Median risk group (M) ≤121.9 54.4 2.09 1.56–2.80 L v H < 0.0001 1.35 0.92–1.98 L v H < 0.0001
  High risk group (H) 121.9+ 35.5 3.54 2.58–4.86 M v H = 0.0002 3.81 2.46–5.91 M v H < 0.0001
 Stage IIIA
  Low risk group (L) ≤60.0 94.6 ref   L v M < 0.0001 ref   L v M < 0.0316
  Median risk group (M) ≤90.4 84.3 3.67 2.76–4.87 L v H < 0.0001 2.10 1.36–3.25 L v H < 0.0001
  High risk group (H) 90.4+ 59.4 11.71 8.66–15.84 M v H < 0.0001 9.07 5.70–14.45 M v H < 0.0001
 Stage IIIB
  Low risk group (L) ≤91.0 82.3 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤116.9 63.7 2.28 2.09–2.48 L v H < 0.0001 2.72 2.42–3.07 L v H < 0.0001
  High risk group (H) 116.9+ 36.6 5.06 4.60–5.56 M v H < 0.0001 6.55 5.75–7.47 M v H < 0.0001
 Stage IIIC
  Low risk group (L) ≤110.6 63.3 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤137.0 35.7 2.10 1.86–2.37 L v H < 0.0001 1.94 1.68–2.24 L v H < 0.0001
  High risk group (H) 137.0+ 18.2 3.97 3.47–4.55 M v H < 0.0001 4.33 3.68–5.11 M v H < 0.0001
 Stage IV
  Low risk group (L) ≤157.2 24.2 ref   L v M < 0.0001 ref   L v M < 0.0001
  Median risk group (M) ≤183.3 9.9 1.59 1.49–1.69 L v H < 0.0001 1.87 1.73–2.03 L v H < 0.0001
  High risk group (H) 183.3+ 3.0 2.79 2.58–3.01 M v H < 0.0001 3.51 3.19–3.88 M v H < 0.0001
  1. AJCC American joint committee on cancer, HR hazard ratio, 95 % CI 95 % confident interval, L low risk group, M median risk group, H high risk group