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Table 3 Univariate Analysis of Overall Survival

From: Oligo-recurrence predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lung cancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional study of 61 subjects

Variable

No.

Survival time, median (ranqe), mo

p value

Age, median (range), y

 <65

30

26 (17.2–34.8)

0.962

 ≥65

31

26 (8.3–43.8)

Sex

 Male

30

32 (12.9–51.1)

0.489

 Female

31

24 (13.8–34.2)

No. of metastatic/recurrent lesions

 1–2

54

32 (18.0–46.0)

0.031

 3–5

7

18 (10.3–25.7)

Oligostatus

 Oligometastases (primary active)

11

18 (14.8–21.2)

0.001

 Oligo-recurrence (primary controlled)

50

41 (27.8–54.2)

Histological status

 Squamous cell carcinoma

6

32 (18.4–45.6)

0.233

 Adenocarcinoma

48

19 (7.0–31.0)

 Others

7

19 (8.7–29.3)

KPS score

 70–80

5

24 (9.9–38.1)

0.169

 90–100

56

32 (19.2–44.8)

Interval to brain recurrence, months

 <12

29

19 (14.9–23.2)

0.081

 ≥12

32

41 (34.6–47.4)

No. of brain metastases

 Single

42

26 (11.3–40.7)

0.817

 2–4

19

26 (16.5–35.5)

RPA

 Class I

26

30 (8.6–51.4)

0.319

 Class II

35

25 (10.6–39.4)

GPA

 Intermediate Prognosis Group (1.5–3.0)

50

26 (16.9–35.1)

0.577

 Favorable Prognosis Group (3.5–4.0)

11

25 (0.0–51.8)

Neurologic function a

 Grade 0–1

40

26 (11.1–40.9)

0.945

 Grade 2–4

21

26 (16.5–35.5)

Treatment method for brain tumor

 SRS

45

26 (17.3–34.7)

0.792

 SRT

16

25 (1.7–48.3)

WBRT

 Yes

9

25 (11.1–38.9)

0.774

 No

52

26 (12.0–40.0)

Thoracic stage b

 I–II

27

25 (16.8–33.2)

0.199

 III

34

37 (20.1–53.9)

Treatment method for thoracic lesions

 Surgery

43

30 (20.2–39.8)

0.94

 Radiation therapy

18

25 (3.2–46.8)

Chemotherapy

 Yes

19

26 (24.1–27.9)

0.975

 No

42

30 (9.0–51.0)

  1. Abbreviations: KPS Karnofsky performance status, RPA recursive partition analysis, GPR graded prognostic assessment, SRS stereotactic radiosurgery, SRT stereotactic radiotherapy, WBRT whole brain radiation therapy
  2. aNeurologic function, grade 0 as no symptoms; grade 1 as minor symptoms, fully active without assistance; grade 2 as moderate symptoms, fully active but requires assistance; grade 3 as moderate symptoms, less than fully active, requires assistance; grade 4 as severe symptoms, totally inactive
  3. bThoracic stage classified according to the TNM classification of malignant tumors version 6 (UICC, Union for International Cancer Control version 6 edition) not evaluating M stage