Fig. 2

Predictive value of gene expression profiles. Patients were grouped into responders and non-responders judged by histological evaluation of tissue samples (regression; a), serum levels of CA125 (decline; b), PCI (improved; c) or volume of ascites (reduction; d). Panel e shows patients grouped as high (response in ≥2 categories) and low responders (response in <2 categories). Corresponding samples obtained before the first IPC and histologically confirmed as tumors were analyzed. The magnitude of the mean expression level ratios of the groups is indicated by different levels of gray (from <1.5-fold, lightest gray to >8-fold, darkest gray). Arrowheads indicate whether the expression is higher (up) or lower (down) in the respective response group (or high responders in E, respectively). The numbers of genes expressed higher/lower are indicated at the far right. Statistical significance of differences between the groups (Mann–Whitney rank sum test) is indicated by asterisks (*, p < 0.05). Panel f shows overall survival of high and low responders (Kaplan-Meier log rank analysis). A color version of the figure is available in Additional file 8