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Fig. 1 | BMC Cancer

Fig. 1

From: Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer

Fig. 1

Analysis of caspase-8 polymorphisms in breast cancer patients. a Schematic overview of the caspase-8 gene and localization of the caspase 8 polymorphisms of interest. The non-coding CASP8 -652 6N InsDel polymorphism, a functional 6 bp deletion, is located in the promoter region of the CASP8 gene, whereas the Asp302His polymorphism is located in the coding region (exon 9). b CASP8 mRNA expression in primary breast cancer tissue by the -652 6N InsDel genotypes. Indicated p-value was calculated by linear ANOVA. c–d Kaplan-Meier curves comparing overall survival of breast cancer patients by the -652 6N InsDel or CASP8 Asp302His genotypes, respectively. e Overview of possible diplotypes. Five patients belonged to rare diplotypes and needed to be analyzed together with other patients. The figure shows how we joined these rare diplotype carriers with the common ones. f Kaplan-Meier curves comparing overall survival of breast cancer patients with regard to the diplotypes of the -652 6N InsDel and Asp302His polymorphisms

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