Table 3 Incidences of serious toxicities during radiotherapy course between IC + RT and CCRT groups
Toxicity | IC + RT (%,N = 73) | CCRT (%,N = 30) | P | ||
|---|---|---|---|---|---|
Grade 3 | Grade 4 | Grade 3 | Grade 4 | ||
Acute toxicity | |||||
 Leukopenia | 5(6.8) | 0 | 7(23.3) | 2(6.7) | 0.005 |
 Granulocytopenia | 4(5.5) | 0 | 6(20.0) | 2(6.7) | 0.007 |
 Thrombocytopenia | 2(2.7) | 0 | 3(10.0) | 1(3.3) | 0.105 |
 Anemia | 2(2.7) | 1(1.4) | 4(13.3) | 2(6.7) | 0.027 |
 Vomiting | 0 | 0 | 2(6.7) | 0 | 0.149 |
 Mucositis | 25(34.2) | 0 | 16(53.3) | 3(10.0) | 0.007 |
 Skin reaction | 3(4.1) | 0 | 5(16.7) | 1(3.3) | 0.027 |
 Hepatic impairment | 1(1.4) | 0 | 1(3.3) | 0 | 1.000 |
 Renal impairment | 0 | 0 | 0 | 0 |  |
 Weight loss | 3(4.1) | 0 | 5(16.7) | 2(6.7) | 2(6.7) |
Late toxicity | |||||
 Xerostomia | 3(4.1) | 0 | 2(6.7) | 0 | 0.965 |
 Subcutaneous Fibrosis | 5(6.8) | 0 | 2(6.7) | 0 | 1.000 |
 Temporal lobe necrosis | 2(2.7) | 0 | 1(3.3) | 0 | 1.000 |
 Trismus | 2(2.7) | 0 | 0 | 0 | 0.897 |
 Dysphagia | 3(4.1) | 0 | 2(6.7) | 0 | 0.965 |
 Cranial neuropathy | 1(1.4) | 0 | 0 | 0 | 1.000 |