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Table 3 Incidences of serious toxicities during radiotherapy course between IC + RT and CCRT groups

From: Induction Chemotherapy Followed by Radiotherapy versus Concurrent Chemoradiotherapy in elderly patients with nasopharyngeal carcinoma: finding from a propensity-matched analysis

Toxicity IC + RT (%,N = 73) CCRT (%,N = 30) P
Grade 3 Grade 4 Grade 3 Grade 4
Acute toxicity
 Leukopenia 5(6.8) 0 7(23.3) 2(6.7) 0.005
 Granulocytopenia 4(5.5) 0 6(20.0) 2(6.7) 0.007
 Thrombocytopenia 2(2.7) 0 3(10.0) 1(3.3) 0.105
 Anemia 2(2.7) 1(1.4) 4(13.3) 2(6.7) 0.027
 Vomiting 0 0 2(6.7) 0 0.149
 Mucositis 25(34.2) 0 16(53.3) 3(10.0) 0.007
 Skin reaction 3(4.1) 0 5(16.7) 1(3.3) 0.027
 Hepatic impairment 1(1.4) 0 1(3.3) 0 1.000
 Renal impairment 0 0 0 0  
 Weight loss 3(4.1) 0 5(16.7) 2(6.7) 2(6.7)
Late toxicity
 Xerostomia 3(4.1) 0 2(6.7) 0 0.965
 Subcutaneous Fibrosis 5(6.8) 0 2(6.7) 0 1.000
 Temporal lobe necrosis 2(2.7) 0 1(3.3) 0 1.000
 Trismus 2(2.7) 0 0 0 0.897
 Dysphagia 3(4.1) 0 2(6.7) 0 0.965
 Cranial neuropathy 1(1.4) 0 0 0 1.000
  1. IC + RT induction chemotherapy followed by radiotherapy, CCRT concurrent chemoradiotherapy