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Table 2 Univariate and multivariate analyses in patients received IC + RT(n = 88) or CCRT(n = 44) after propensity score matching

From: Induction Chemotherapy Followed by Radiotherapy versus Concurrent Chemoradiotherapy in elderly patients with nasopharyngeal carcinoma: finding from a propensity-matched analysis

 

OS

CSS

LRFFS

DFFS

HR (95 % CI)

P

HR (95 % CI)

P

HR (95 % CI)

P

HR (95 % CI)

P

Univeriate parameter

 Age

Continuous variable

1.051(0.977–1.131)

0.185

1.046 (0.967–1.132)

0.261

0.892(0.737–1.079)

0.239

1.044(0.945–1.154)

0.399

 Gender

male vs. female

1.301(0.590–2.869)

0.514

1.119(0.504–2.487)

0.782

2.131(0.277–16.397)

0.467

1.434(0.433–4.751)

0.555

 T-stage

T1-2 vs. T3-4

0.907(0.496–1.659)

0.752

0.974(0.518–1.833)

0.936

2.725(0.915–8.115)

0.072

0.984(0.418–2.320)

0.971

 N-stage

N0-1vs. N2-3

0.902(0.538–1.512)

0.902

1.087(0.628–1.883)

0.765

1.200(0.403–3.570)

0.744

0.763(0.361–1.614)

0.479

 Clinical stage

I-II vs. III-IV

0.805(0.291–2.228)

0.805

0.929(0.334–2.580)

0.887

2.088(0.462–9.430)

0.338

0.436(0.059–3.209)

0.415

 NP dose (Gy)

Continuous variable

1.007(0.930–1.090)

0.862

1.002(0.921–1.090)

0.960

0.925(0.808–1.058)

0.253

1.042(0.923–1.175)

0.510

 LN dose (Gy)

Continuous variable

1.023(0.980–1.068)

0.292

1.021(0.975–1.068)

0.380

0.946(0.871–1.027)

0.187

1.057(0.993–1.125)

0.083

 RT Days

Continuous variable

1.006(0.981–1.032)

0.623

1.010(0.984–1.037)

0.451

0.954(0.887–1.026)

0.203

1.013(0.977–1.050)

0.493

 Treatment group

IC + RT vs. CCRT

0.717(0.421–1.220)

0.220

0.682(0.388–1.198)

0.183

0.747(0.244–2.284)

0.609

1.709(0.693–4.218)

0.245

 Cranial nerve involvement

absent vs. present

0.781(0.354–1.726)

0.542

0.663(0.298–1.476)

0.314

0.581(0.128–2.628)

0.481

0.657(0.228–1.896)

0.437

 Basicranial Bone involvement

absent vs. present

0.553(0.329–0.929)

0.025

0.558(0.321–0.969)

0.038

0.784(0.263–2.341)

0.663

0.712(0.339–1.497)

0.371

 Family history

absent vs. present

1.142(0.413–3.155)

0.798

1.349(0.420–4.335)

0.615

22.74(0.003–25.96)

0.494

0.655(0.197–2.171)

0.489

Multivariate parametera

 Treatment group

IC + RT vs. CCRT

0.706(0.412–1.208)

0.204

0.708(0.402–1.246)

0.231

0.696(0.207–2.342)

0.558

1.627(0.658–4.023)

0.292

 Basicranial Bone involvement

absent vs. present

0.553(0.329–0.929)

0.025

0.558(0.321–0.969)

0.038

0.246(0.044–1.382)

0.111

0.760(0.337–1.715)

0.508

 T-stage

T1-2 vs. T3-4

1.347(0.638–2.842)

0.435

1.490(0.675–3.289)

0.324

6.833(1.224–38.148)

0.028

1.355(0.481–3.819)

0.565

  1. CI confidence interval, IC + RT induction chemotherapy followed by radiotherapy, CCRT concurrent chemoradiotherapy, NP nasopharynx, LN lymph node
  2. aOther covariates not shown (P > 0.05)