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Table 4 Sensitivity Analysis of Thrombocytosis within 2 Weeks of Diagnosis and Overall Ovarian Cancer Survival

From: Thresholds and timing of pre-operative thrombocytosis and ovarian cancer survival: analysis of laboratory measures from electronic medical records

 

Thrombocytosis

No Thrombocytosis

Unadjusted Association

Multivariable Associationa

Thrombocytosis

N Cases

N Events

N Cases

N Events

HR

95 % CI

P-value*

HR

95 % CI

P-value*

Defined by ≥350 × 109/L

 2 weeks to date of diagnosis

147

106

133

72

1.96

1.45–2.66

<0.001

1.78

1.31–2.44

<0.001

  Excluding low malignant potential tumors

147

106

121

71

1.71

1.26–2.32

<0.001

1.67

1.22–2.28

0.001

  Excluding synchronous cancers

134

101

124

71

1.94

1.42–2.64

<0.001

1.72

1.26–2.36

<0.001

  Excluding non–Whites

128

91

114

61

1.92

1.38–2.68

<0.001

1.88

1.34–2.62

<0.001

  Excluding unknown stage of disease

134

95

124

67

1.89

1.37–2.60

<0.001

1.66

1.20–2.30

0.002

  Excluding unknown histologic subtypes

115

79

104

52

1.81

1.27–2.58

0.001

1.48

1.03–2.13

0.034

  Excluding all of the above cases

84

60

68

40

1.47

0.98–2.20

0.063

1.47

0.98–2.21

0.065

Defined by ≥400 × 109/L

 2 weeks to date of diagnosis

107

78

173

100

1.87

1.39–2.53

<0.001

1.60

1.17–2.18

0.003

  Excluding low malignant potential tumors

107

78

161

99

1.67

1.23–2.26

<0.001

1.50

1.10–2.06

0.010

  Excluding synchronous cancers

96

74

162

98

1.94

1.42–2.64

<0.001

1.61

1.17–2.20

0.003

  Excluding non–Whites

91

64

151

88

1.75

1.26–2.43

<0.001

1.58

1.13–2.21

0.008

  Excluding unknown stage of disease

96

69

162

93

1.84

1.34–2.52

<0.001

1.49

1.08–2.07

0.016

  Excluding unknown histologic subtypes

84

59

135

72

1.81

1.28–2.57

<0.001

1.37

0.95–1.97

0.089

  Excluding all of the above cases

59

44

93

56

1.69

1.13–2.53

0.011

1.46

0.97–2.20

0.072

Defined by ≥450 × 109/L

 2 weeks to date of diagnosis

72

55

208

123

1.91

1.38–2.65

<0.001

1.62

1.16–2.27

0.005

  Excluding low malignant potential tumors

72

55

196

122

1.73

1.25–2.39

<0.001

1.53

1.09–2.14

0.014

  Excluding synchronous cancers

64

51

194

121

1.92

1.38–2.68

<0.001

1.66

1.17–2.34

0.004

  Excluding non–Whites

60

44

182

108

1.82

1.27–2.61

0.001

1.65

1.14–2.40

0.008

  Excluding unknown stage of disease

63

47

195

115

1.88

1.33–2.65

<0.001

1.51

1.05–2.15

0.024

  Excluding unknown histologic subtypes

54

41

165

90

1.81

1.24–2.63

0.002

1.31

0.88–1.94

0.186

  Excluding all of the above cases

37

29

115

71

1.73

1.11–2.70

0.016

1.49

0.93–2.37

0.096

  1. *Bold type denotes significant associations
  2. aAdjusted for age at diagnosis, stage, grade, and histologic subtype as appropriate after exclusions