| Thrombocytosis | No Thrombocytosis | Unadjusted Association | Multivariable Associationa | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Thrombocytosis | N Cases | N Events | N Cases | N Events | HR | 95Â % CI | P-value* | HR | 95Â % CI | P-value* |
Defined by ≥350 × 109/L | ||||||||||
 2 weeks to date of diagnosis | 147 | 106 | 133 | 72 | 1.96 | 1.45–2.66 | <0.001 | 1.78 | 1.31–2.44 | <0.001 |
  Excluding low malignant potential tumors | 147 | 106 | 121 | 71 | 1.71 | 1.26–2.32 | <0.001 | 1.67 | 1.22–2.28 | 0.001 |
  Excluding synchronous cancers | 134 | 101 | 124 | 71 | 1.94 | 1.42–2.64 | <0.001 | 1.72 | 1.26–2.36 | <0.001 |
  Excluding non–Whites | 128 | 91 | 114 | 61 | 1.92 | 1.38–2.68 | <0.001 | 1.88 | 1.34–2.62 | <0.001 |
  Excluding unknown stage of disease | 134 | 95 | 124 | 67 | 1.89 | 1.37–2.60 | <0.001 | 1.66 | 1.20–2.30 | 0.002 |
  Excluding unknown histologic subtypes | 115 | 79 | 104 | 52 | 1.81 | 1.27–2.58 | 0.001 | 1.48 | 1.03–2.13 | 0.034 |
  Excluding all of the above cases | 84 | 60 | 68 | 40 | 1.47 | 0.98–2.20 | 0.063 | 1.47 | 0.98–2.21 | 0.065 |
Defined by ≥400 × 109/L | ||||||||||
 2 weeks to date of diagnosis | 107 | 78 | 173 | 100 | 1.87 | 1.39–2.53 | <0.001 | 1.60 | 1.17–2.18 | 0.003 |
  Excluding low malignant potential tumors | 107 | 78 | 161 | 99 | 1.67 | 1.23–2.26 | <0.001 | 1.50 | 1.10–2.06 | 0.010 |
  Excluding synchronous cancers | 96 | 74 | 162 | 98 | 1.94 | 1.42–2.64 | <0.001 | 1.61 | 1.17–2.20 | 0.003 |
  Excluding non–Whites | 91 | 64 | 151 | 88 | 1.75 | 1.26–2.43 | <0.001 | 1.58 | 1.13–2.21 | 0.008 |
  Excluding unknown stage of disease | 96 | 69 | 162 | 93 | 1.84 | 1.34–2.52 | <0.001 | 1.49 | 1.08–2.07 | 0.016 |
  Excluding unknown histologic subtypes | 84 | 59 | 135 | 72 | 1.81 | 1.28–2.57 | <0.001 | 1.37 | 0.95–1.97 | 0.089 |
  Excluding all of the above cases | 59 | 44 | 93 | 56 | 1.69 | 1.13–2.53 | 0.011 | 1.46 | 0.97–2.20 | 0.072 |
Defined by ≥450 × 109/L | ||||||||||
 2 weeks to date of diagnosis | 72 | 55 | 208 | 123 | 1.91 | 1.38–2.65 | <0.001 | 1.62 | 1.16–2.27 | 0.005 |
  Excluding low malignant potential tumors | 72 | 55 | 196 | 122 | 1.73 | 1.25–2.39 | <0.001 | 1.53 | 1.09–2.14 | 0.014 |
  Excluding synchronous cancers | 64 | 51 | 194 | 121 | 1.92 | 1.38–2.68 | <0.001 | 1.66 | 1.17–2.34 | 0.004 |
  Excluding non–Whites | 60 | 44 | 182 | 108 | 1.82 | 1.27–2.61 | 0.001 | 1.65 | 1.14–2.40 | 0.008 |
  Excluding unknown stage of disease | 63 | 47 | 195 | 115 | 1.88 | 1.33–2.65 | <0.001 | 1.51 | 1.05–2.15 | 0.024 |
  Excluding unknown histologic subtypes | 54 | 41 | 165 | 90 | 1.81 | 1.24–2.63 | 0.002 | 1.31 | 0.88–1.94 | 0.186 |
  Excluding all of the above cases | 37 | 29 | 115 | 71 | 1.73 | 1.11–2.70 | 0.016 | 1.49 | 0.93–2.37 | 0.096 |