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Table 4 Sensitivity Analysis of Thrombocytosis within 2 Weeks of Diagnosis and Overall Ovarian Cancer Survival

From: Thresholds and timing of pre-operative thrombocytosis and ovarian cancer survival: analysis of laboratory measures from electronic medical records

  Thrombocytosis No Thrombocytosis Unadjusted Association Multivariable Associationa
Thrombocytosis N Cases N Events N Cases N Events HR 95 % CI P-value* HR 95 % CI P-value*
Defined by ≥350 × 109/L
 2 weeks to date of diagnosis 147 106 133 72 1.96 1.45–2.66 <0.001 1.78 1.31–2.44 <0.001
  Excluding low malignant potential tumors 147 106 121 71 1.71 1.26–2.32 <0.001 1.67 1.22–2.28 0.001
  Excluding synchronous cancers 134 101 124 71 1.94 1.42–2.64 <0.001 1.72 1.26–2.36 <0.001
  Excluding non–Whites 128 91 114 61 1.92 1.38–2.68 <0.001 1.88 1.34–2.62 <0.001
  Excluding unknown stage of disease 134 95 124 67 1.89 1.37–2.60 <0.001 1.66 1.20–2.30 0.002
  Excluding unknown histologic subtypes 115 79 104 52 1.81 1.27–2.58 0.001 1.48 1.03–2.13 0.034
  Excluding all of the above cases 84 60 68 40 1.47 0.98–2.20 0.063 1.47 0.98–2.21 0.065
Defined by ≥400 × 109/L
 2 weeks to date of diagnosis 107 78 173 100 1.87 1.39–2.53 <0.001 1.60 1.17–2.18 0.003
  Excluding low malignant potential tumors 107 78 161 99 1.67 1.23–2.26 <0.001 1.50 1.10–2.06 0.010
  Excluding synchronous cancers 96 74 162 98 1.94 1.42–2.64 <0.001 1.61 1.17–2.20 0.003
  Excluding non–Whites 91 64 151 88 1.75 1.26–2.43 <0.001 1.58 1.13–2.21 0.008
  Excluding unknown stage of disease 96 69 162 93 1.84 1.34–2.52 <0.001 1.49 1.08–2.07 0.016
  Excluding unknown histologic subtypes 84 59 135 72 1.81 1.28–2.57 <0.001 1.37 0.95–1.97 0.089
  Excluding all of the above cases 59 44 93 56 1.69 1.13–2.53 0.011 1.46 0.97–2.20 0.072
Defined by ≥450 × 109/L
 2 weeks to date of diagnosis 72 55 208 123 1.91 1.38–2.65 <0.001 1.62 1.16–2.27 0.005
  Excluding low malignant potential tumors 72 55 196 122 1.73 1.25–2.39 <0.001 1.53 1.09–2.14 0.014
  Excluding synchronous cancers 64 51 194 121 1.92 1.38–2.68 <0.001 1.66 1.17–2.34 0.004
  Excluding non–Whites 60 44 182 108 1.82 1.27–2.61 0.001 1.65 1.14–2.40 0.008
  Excluding unknown stage of disease 63 47 195 115 1.88 1.33–2.65 <0.001 1.51 1.05–2.15 0.024
  Excluding unknown histologic subtypes 54 41 165 90 1.81 1.24–2.63 0.002 1.31 0.88–1.94 0.186
  Excluding all of the above cases 37 29 115 71 1.73 1.11–2.70 0.016 1.49 0.93–2.37 0.096
  1. *Bold type denotes significant associations
  2. aAdjusted for age at diagnosis, stage, grade, and histologic subtype as appropriate after exclusions