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Table 3 Thrombocytosis and Overall Survival Among Ovarian Cancer Cases from the Vanderbilt University Medical Center

From: Thresholds and timing of pre-operative thrombocytosis and ovarian cancer survival: analysis of laboratory measures from electronic medical records

  Thrombocytosis No Thrombocytosis (Reference) Unadjusted Association Multivariable Associationa
Thrombocytosis % N Cases N Events N Cases N Events HR 95 % CI P-value* HR 95 % CI P-value*
Defined by ≥350 × 109/L
 Date of diagnosis 44.8 61 42 75 46 1.45 0.94–2.23 0.093 1.55 0.97–2.47 0.070
 1 week prior to date of diagnosis 53.1 128 96 113 63 2.09 1.51–2.89 <0.001 1.83 1.30–2.58 0.001
 2 week prior to date of diagnosis 52.5 147 106 133 72 1.96 1.47–2.66 <0.001 1.79 1.31–2.44 <0.001
 4 week prior to date of diagnosis 53.2 158 110 139 73 1.94 1.44–2.62 <0.001 1.80 1.33–2.45 <0.001
 8 week prior to date of diagnosis 52.3 159 111 145 77 1.92 1.43–2.58 <0.001 1.80 1.33–2.43 <0.001
Defined by ≥400 × 109/L
 Date of diagnosis 31.6 43 33 93 60 1.98 1.27–3.09 0.003 2.01 1.25–3.23 0.004
 1 week prior to date of diagnosis 39.4 95 73 146 94 1.92 1.39–2.64 <0.001 1.62 1.16–2.26 0.005
 2 week prior to date of diagnosis 38.2 107 79 173 108 1.87 1.39–2.53 <0.001 1.60 1.17–2.18 0.003
 4 week prior to date of diagnosis 38.1 113 80 184 112 1.78 1.32–2.40 <0.001 1.54 1.14–2.09 0.006
 8 week prior to date of diagnosis 37.5 114 81 190 116 1.78 1.33–2.40 <0.001 1.55 1.14–2.10 0.005
Defined by ≥450 × 109/L
 Date of diagnosis 19.9 27 22 109 71 1.98 1.21–3.27 0.007 2.00 1.16–3.46 0.013
 1 week prior to date of diagnosis 26.1 63 51 178 116 2.01 1.43–2.82 <0.001 1.71 1.20–2.45 0.003
 2 week prior to date of diagnosis 25.7 72 55 208 132 1.91 1.38–2.65 <0.001 1.62 1.16–2.27 0.005
 4 week prior to date of diagnosis 24.9 74 56 223 136 1.88 1.37–2.59 <0.001 1.56 1.12–2.17 0.008
 8 week prior to date of diagnosis 25.0 76 57 228 140 1.79 1.30–2.45 <0.001 1.55 1.12–2.15 0.009
  1. *Bold type denotes significant associations
  2. aAdjusted for age at diagnosis, stage, grade, and histologic subtype