| Thrombocytosis | No Thrombocytosis (Reference) | Unadjusted Association | Multivariable Associationa | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Thrombocytosis | % | N Cases | N Events | N Cases | N Events | HR | 95Â % CI | P-value* | HR | 95Â % CI | P-value* |
Defined by ≥350 × 109/L | |||||||||||
 Date of diagnosis | 44.8 | 61 | 42 | 75 | 46 | 1.45 | 0.94–2.23 | 0.093 | 1.55 | 0.97–2.47 | 0.070 |
 1 week prior to date of diagnosis | 53.1 | 128 | 96 | 113 | 63 | 2.09 | 1.51–2.89 | <0.001 | 1.83 | 1.30–2.58 | 0.001 |
 2 week prior to date of diagnosis | 52.5 | 147 | 106 | 133 | 72 | 1.96 | 1.47–2.66 | <0.001 | 1.79 | 1.31–2.44 | <0.001 |
 4 week prior to date of diagnosis | 53.2 | 158 | 110 | 139 | 73 | 1.94 | 1.44–2.62 | <0.001 | 1.80 | 1.33–2.45 | <0.001 |
 8 week prior to date of diagnosis | 52.3 | 159 | 111 | 145 | 77 | 1.92 | 1.43–2.58 | <0.001 | 1.80 | 1.33–2.43 | <0.001 |
Defined by ≥400 × 109/L | |||||||||||
 Date of diagnosis | 31.6 | 43 | 33 | 93 | 60 | 1.98 | 1.27–3.09 | 0.003 | 2.01 | 1.25–3.23 | 0.004 |
 1 week prior to date of diagnosis | 39.4 | 95 | 73 | 146 | 94 | 1.92 | 1.39–2.64 | <0.001 | 1.62 | 1.16–2.26 | 0.005 |
 2 week prior to date of diagnosis | 38.2 | 107 | 79 | 173 | 108 | 1.87 | 1.39–2.53 | <0.001 | 1.60 | 1.17–2.18 | 0.003 |
 4 week prior to date of diagnosis | 38.1 | 113 | 80 | 184 | 112 | 1.78 | 1.32–2.40 | <0.001 | 1.54 | 1.14–2.09 | 0.006 |
 8 week prior to date of diagnosis | 37.5 | 114 | 81 | 190 | 116 | 1.78 | 1.33–2.40 | <0.001 | 1.55 | 1.14–2.10 | 0.005 |
Defined by ≥450 × 109/L | |||||||||||
 Date of diagnosis | 19.9 | 27 | 22 | 109 | 71 | 1.98 | 1.21–3.27 | 0.007 | 2.00 | 1.16–3.46 | 0.013 |
 1 week prior to date of diagnosis | 26.1 | 63 | 51 | 178 | 116 | 2.01 | 1.43–2.82 | <0.001 | 1.71 | 1.20–2.45 | 0.003 |
 2 week prior to date of diagnosis | 25.7 | 72 | 55 | 208 | 132 | 1.91 | 1.38–2.65 | <0.001 | 1.62 | 1.16–2.27 | 0.005 |
 4 week prior to date of diagnosis | 24.9 | 74 | 56 | 223 | 136 | 1.88 | 1.37–2.59 | <0.001 | 1.56 | 1.12–2.17 | 0.008 |
 8 week prior to date of diagnosis | 25.0 | 76 | 57 | 228 | 140 | 1.79 | 1.30–2.45 | <0.001 | 1.55 | 1.12–2.15 | 0.009 |