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Table 3 Thrombocytosis and Overall Survival Among Ovarian Cancer Cases from the Vanderbilt University Medical Center

From: Thresholds and timing of pre-operative thrombocytosis and ovarian cancer survival: analysis of laboratory measures from electronic medical records

 

Thrombocytosis

No Thrombocytosis (Reference)

Unadjusted Association

Multivariable Associationa

Thrombocytosis

%

N Cases

N Events

N Cases

N Events

HR

95 % CI

P-value*

HR

95 % CI

P-value*

Defined by ≥350 × 109/L

 Date of diagnosis

44.8

61

42

75

46

1.45

0.94–2.23

0.093

1.55

0.97–2.47

0.070

 1 week prior to date of diagnosis

53.1

128

96

113

63

2.09

1.51–2.89

<0.001

1.83

1.30–2.58

0.001

 2 week prior to date of diagnosis

52.5

147

106

133

72

1.96

1.47–2.66

<0.001

1.79

1.31–2.44

<0.001

 4 week prior to date of diagnosis

53.2

158

110

139

73

1.94

1.44–2.62

<0.001

1.80

1.33–2.45

<0.001

 8 week prior to date of diagnosis

52.3

159

111

145

77

1.92

1.43–2.58

<0.001

1.80

1.33–2.43

<0.001

Defined by ≥400 × 109/L

 Date of diagnosis

31.6

43

33

93

60

1.98

1.27–3.09

0.003

2.01

1.25–3.23

0.004

 1 week prior to date of diagnosis

39.4

95

73

146

94

1.92

1.39–2.64

<0.001

1.62

1.16–2.26

0.005

 2 week prior to date of diagnosis

38.2

107

79

173

108

1.87

1.39–2.53

<0.001

1.60

1.17–2.18

0.003

 4 week prior to date of diagnosis

38.1

113

80

184

112

1.78

1.32–2.40

<0.001

1.54

1.14–2.09

0.006

 8 week prior to date of diagnosis

37.5

114

81

190

116

1.78

1.33–2.40

<0.001

1.55

1.14–2.10

0.005

Defined by ≥450 × 109/L

 Date of diagnosis

19.9

27

22

109

71

1.98

1.21–3.27

0.007

2.00

1.16–3.46

0.013

 1 week prior to date of diagnosis

26.1

63

51

178

116

2.01

1.43–2.82

<0.001

1.71

1.20–2.45

0.003

 2 week prior to date of diagnosis

25.7

72

55

208

132

1.91

1.38–2.65

<0.001

1.62

1.16–2.27

0.005

 4 week prior to date of diagnosis

24.9

74

56

223

136

1.88

1.37–2.59

<0.001

1.56

1.12–2.17

0.008

 8 week prior to date of diagnosis

25.0

76

57

228

140

1.79

1.30–2.45

<0.001

1.55

1.12–2.15

0.009

  1. *Bold type denotes significant associations
  2. aAdjusted for age at diagnosis, stage, grade, and histologic subtype