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Table 2 Associations Between Thrombocytosis within 8 Weeks of Diagnosis and Clinical Covariates among Ovarian Cancer Cases from the Vanderbilt University Medical Center

From: Thresholds and timing of pre-operative thrombocytosis and ovarian cancer survival: analysis of laboratory measures from electronic medical records

  Thrombocytosis (>350 × 109/L) Thrombocytosis (>400 × 109/L) Thrombocytosis (>450 × 109/L)
No (N = 145) Yes (N = 159)   No (N = 190) Yes (N = 114)   No (N = 228) Yes (N = 76)  
Characteristic N or mean (% or std dev)a P-value** N or mean (% or std dev)a P-value** N or mean (% or std dev)a P-value**
Age at Diagnosis, years 60.7 (14.1) 59.9 (14.8) 0.631 60.9 (14.3) 59.1 (14.8) 0.275 60.4 (14.4) 59.8 (14.8) 0.746
Race
 White 128 (88.3) 138 (86.8) 0.696 169 (89.0) 97 (85.1) 0.325 202 (88.6) 64 (84.2) 0.317
 Other/Unknown 17 (11.7) 21 (13.2) 21 (11.1) 17 (14.9) 26 (11.4) 12 (15.8)
Primary Site
 Ovary (C569) 137 (94.5) 157 (98.7) 0.052 † 114 (100.0) 114 (100.0) 0.015 † 218 (95.6) 76 (100.0) 0.072 †
 Fallopian Tube (C570) 17 (5.5) 2 (1.3) 0 (0.0) 0 (0.0) 10 (4.4) 0 (0.0)
Histologic Subtype
 Serous 68 (46.9) 79 (49.7) 0.691 88 (46.3) 59 (51.8) 0.629 111 (48.7) 36 (47.4) 0.414
 Endometrioid 14 (9.7) 19 (12.0) 20 (10.5) 13 (11.4) 24 (10.5) 9 (11.8)
 Mucinous 15 (10.3) 9 (5.7) 19 (10.0) 5 (4.4) 22 (9.7) 2 (2.6)
 Clear Cell 6 (4.1) 9 (5.7) 9 (4.7) 6 (5.3) 10 (4.4) 5 (6.6)
 Other 9 (6.2) 9 (5.7) 11 (5.8) 7 (6.1) 12 (5.3) 6 (7.9)
 Unknown 33 (22.8) 34 (21.4) 43 (22.6) 24 (21.1) 49 (21.5) 18 (23.7)
 Serous 68 (46.9) 79 (49.7) 0.888 88 (46.3) 59 (51.8) 0.646 111 (48.7) 36 (47.4) 0.923
 Non-Serous 44 (30.3) 46 (28.9) 59 (31.1) 31 (27.2) 68 (29.8) 22 (29.0)
 Unknown 33 (22.8) 34 (21.4) 43 (22.6) 24 (21.1) 49 (21.5) 18 (23.7)
Stage of Disease
 I 43 (29.7) 26 (16.4) 0.051 52 (27.4) 17 (14.9) 0.038 59 (25.9) 10 (13.2) 0.009
 II 10 (6.9) 9 (5.7) 14 (7.4) 5 (4.4) 17 (7.5) 2 (2.6)
 III 56 (38.6) 68 (42.8) 76 (40.0) 48 (42.1) 94 (41.2) 30 (39.5)
 IV 25 (17.2) 42 (26.4) 35 (18.4) 32 (28.1) 43 (18.9) 24 (31.6)
 Unknown/Unstaged 11 (7.6) 14 (8.8) 13 (6.8) 12 (10.5) 15 (6.6) 10 (13.2)
Disease Grade
 1, Well differentiated 10 (6.9) 11 (6.9) 0.115 15 (7.9) 6 (5.3) 0.008 18 (7.9) 3 (4.0) 0.010
 2, Moderately differentiated 21 (14.5) 23 (14.5) 29 (15.3) 15 (13.2) 36 (15.8) 8 (10.5)
 3, Poorly differentiated 57 (39.3) 63 (39.6) 78 (41.1) 42 (36.8) 90 (39.5) 30 (39.5)
 4, Undifferentiated 10 (6.9) 25 (15.7) 12 (6.3) 23 (20.2) 18 (7.9) 17 (22.4)
 Unknown 47 (32.4) 37 (23.3) 56 (29.5) 28 (24.6) 66 (29.0) 18 (23.7)
  1. aPercentages may not sum to 100 % due to rounding error
  2. **P-values from χ2 test or Fisher’s exact test where indicated (†); bold values denote significant associations