Table 2 Associations Between Thrombocytosis within 8 Weeks of Diagnosis and Clinical Covariates among Ovarian Cancer Cases from the Vanderbilt University Medical Center
|  | Thrombocytosis (>350 × 109/L) | Thrombocytosis (>400 × 109/L) | Thrombocytosis (>450 × 109/L) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No (N = 145) | Yes (N = 159) |  | No (N = 190) | Yes (N = 114) |  | No (N = 228) | Yes (N = 76) |  | |||||||
Characteristic | N or mean | (% or std dev)a | P-value** | N or mean | (% or std dev)a | P-value** | N or mean | (% or std dev)a | P-value** | ||||||
Age at Diagnosis, years | 60.7 | (14.1) | 59.9 | (14.8) | 0.631 | 60.9 | (14.3) | 59.1 | (14.8) | 0.275 | 60.4 | (14.4) | 59.8 | (14.8) | 0.746 |
Race | |||||||||||||||
 White | 128 | (88.3) | 138 | (86.8) | 0.696 | 169 | (89.0) | 97 | (85.1) | 0.325 | 202 | (88.6) | 64 | (84.2) | 0.317 |
 Other/Unknown | 17 | (11.7) | 21 | (13.2) | 21 | (11.1) | 17 | (14.9) | 26 | (11.4) | 12 | (15.8) | |||
Primary Site | |||||||||||||||
 Ovary (C569) | 137 | (94.5) | 157 | (98.7) | 0.052 †| 114 | (100.0) | 114 | (100.0) | 0.015 †| 218 | (95.6) | 76 | (100.0) | 0.072 †|
 Fallopian Tube (C570) | 17 | (5.5) | 2 | (1.3) | 0 | (0.0) | 0 | (0.0) | 10 | (4.4) | 0 | (0.0) | |||
Histologic Subtype | |||||||||||||||
 Serous | 68 | (46.9) | 79 | (49.7) | 0.691 | 88 | (46.3) | 59 | (51.8) | 0.629 | 111 | (48.7) | 36 | (47.4) | 0.414 |
 Endometrioid | 14 | (9.7) | 19 | (12.0) | 20 | (10.5) | 13 | (11.4) | 24 | (10.5) | 9 | (11.8) | |||
 Mucinous | 15 | (10.3) | 9 | (5.7) | 19 | (10.0) | 5 | (4.4) | 22 | (9.7) | 2 | (2.6) | |||
 Clear Cell | 6 | (4.1) | 9 | (5.7) | 9 | (4.7) | 6 | (5.3) | 10 | (4.4) | 5 | (6.6) | |||
 Other | 9 | (6.2) | 9 | (5.7) | 11 | (5.8) | 7 | (6.1) | 12 | (5.3) | 6 | (7.9) | |||
 Unknown | 33 | (22.8) | 34 | (21.4) | 43 | (22.6) | 24 | (21.1) | 49 | (21.5) | 18 | (23.7) | |||
 Serous | 68 | (46.9) | 79 | (49.7) | 0.888 | 88 | (46.3) | 59 | (51.8) | 0.646 | 111 | (48.7) | 36 | (47.4) | 0.923 |
 Non-Serous | 44 | (30.3) | 46 | (28.9) | 59 | (31.1) | 31 | (27.2) | 68 | (29.8) | 22 | (29.0) | |||
 Unknown | 33 | (22.8) | 34 | (21.4) | 43 | (22.6) | 24 | (21.1) | 49 | (21.5) | 18 | (23.7) | |||
Stage of Disease | |||||||||||||||
 I | 43 | (29.7) | 26 | (16.4) | 0.051 | 52 | (27.4) | 17 | (14.9) | 0.038 | 59 | (25.9) | 10 | (13.2) | 0.009 |
 II | 10 | (6.9) | 9 | (5.7) | 14 | (7.4) | 5 | (4.4) | 17 | (7.5) | 2 | (2.6) | |||
 III | 56 | (38.6) | 68 | (42.8) | 76 | (40.0) | 48 | (42.1) | 94 | (41.2) | 30 | (39.5) | |||
 IV | 25 | (17.2) | 42 | (26.4) | 35 | (18.4) | 32 | (28.1) | 43 | (18.9) | 24 | (31.6) | |||
 Unknown/Unstaged | 11 | (7.6) | 14 | (8.8) | 13 | (6.8) | 12 | (10.5) | 15 | (6.6) | 10 | (13.2) | |||
Disease Grade | |||||||||||||||
 1, Well differentiated | 10 | (6.9) | 11 | (6.9) | 0.115 | 15 | (7.9) | 6 | (5.3) | 0.008 | 18 | (7.9) | 3 | (4.0) | 0.010 |
 2, Moderately differentiated | 21 | (14.5) | 23 | (14.5) | 29 | (15.3) | 15 | (13.2) | 36 | (15.8) | 8 | (10.5) | |||
 3, Poorly differentiated | 57 | (39.3) | 63 | (39.6) | 78 | (41.1) | 42 | (36.8) | 90 | (39.5) | 30 | (39.5) | |||
 4, Undifferentiated | 10 | (6.9) | 25 | (15.7) | 12 | (6.3) | 23 | (20.2) | 18 | (7.9) | 17 | (22.4) | |||
 Unknown | 47 | (32.4) | 37 | (23.3) | 56 | (29.5) | 28 | (24.6) | 66 | (29.0) | 18 | (23.7) | |||