Table 4 Multivariate analysis of factors predicting survival in the entire patient population and in the diabetic patient population

Variable

HR

95 % CI

P

 Gender

1.39

1.13–1.72

0.002

 Smoking History

1.18

0.95–1.44

0.132

 Histology

0.92

0.75–1.12

0.421

 Clinical Stage IIIB-IV

2.03

1.33–3.08

0.001

 ECOG Performance Status

1.26

1.10–1.43

0.001

 Metformin use

0.53

0.37–0.75

<0.0001

 Glycemic control

0.49

0.39–0.63

<0.0001

HR

95 % CI

P

 Gender

1.36

0.80–2.33

0.256

 Smoking History

1.35

0.79–2.31

0.277

 Clinical Stage IIIB-IV

3.01

0.92–9.84

0.068

 Metformin use

0.57

0.36–0.90

0.017

 Proper glycemic control

0.40

0.22–0.71

0.002