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Table 3 Overall survival and patient characteristics of the entire patient population (n = 1106) and the diabetic patient population (n = 186)

From: Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer

 

Entire Patient Population (n = 1106)

Diabetic Patient Population (n = 186)

Characteristic

OS (m)

n

95 % CI

p

OS (m)

n

95 % CI

p

Gender

  

<0.0001

  

0.087

 Female

23.0

520

19.2–26.8

 

26.9

86

13.5–40.4

 

 Male

14.9

586

13–16.9

 

14.3

100

12–16.5

 

Age

  

0.369

  

0.926

 ≤61

18.7

544

16.6–20.9

 

16.4

59

12.2–20.7

 

 > 61

17.4

562

12.8–22

 

18.3

127

7.3–29.2

 

Smoking history

  

0.01

  

0.065

 No

23.8

456

20.1–27.4

 

27.3

82

22.8–31.9

 

 Yes

15.2

650

13.4–17

 

13.8

104

11.8–15.9

 

Histology

  

0.089

  

0.678

 Other

14.2

352

11.1–17.2

 

14.9

60

10.3–19.6

 

 Adenocarcinoma

20.2

754

17.4–23

 

16.4

126

7.5–25.4

 

Stage

  

<0.0001

  

0.012

 II-IIIa

38.5

63

17.3–59.7

 

61.1

12

 

 IIIb-IV

17.2

1043

14.8–19.6

 

15.2

174

12.8–17.6

 

Diabetes

  

0.619

   

 Yes

18.5

186

16.2–20.7

    

 No

16.4

920

8.3–24.5

    

Metformin use

  

0.046

  

0.017

 No

18.3

995

15.9–20.6

 

13.2

75

12.0–14.5

 

 Yes

25.6

111

13.7–37.6

 

25.6

111

13.7–37.6

 

Insulin use

  

0.743

  

0.718

 No

19

1087

16.4–20.4

 

17.0

165

8.4–25.6

 

 Yes

15.8

19

8.6–22.9

 

15.8

21

8.6–23.0

 

Glibenclamide use

  

0.703

  

0.473

 No

18.4

1046

16.4–20.5

 

17.0

126

5.2–28.7

 

 Yes

15.2

60

9.8–20.3

 

15.2

60

9.8–20.6

 

Glycemic control

  

<0.001

  

<0.0001

 Improper (≥130 mg/dLa)

12.1

208

10.1–14.1

 

13.2

127

12–14.4

 

 Proper (<130 mg/dLa)

19.8

887

17.2–22.3

 

40.5

58

11.1–69.8

 

Glycemic control and diabetesb

  

<0.001

   

 Proper diabetic control

40.5

58

11.2–69.8

    

 Improper diabetic control

13.2

127

11.9–14.4

    

 Non-diabetic

18.4

920

16.2–20.8

    
  1. OS Overall Survival, m Months
  2. a Calculated mean serum glucose b One patient with missing glucose values