Skip to main content

Table 3 Association between statin use before diagnosis and breast cancer-specific and all-cause mortality in patients with breast cancer

From: Statin use and breast cancer survival: a nationwide cohort study in Scotland

  Breast cancer mortality Patients Person years Age-adjusted HR (95 % CI) P Adjusteda HR (95 % CI) P
[n = 12,231] [n = 12,230]
Breast cancer mortality
 Statin non-user 834 9,200 29,298 1.00 (ref. cat.)   1.00 (ref. cat.)  
 Statin user 381 3,031 9,125 0.98 (0.86, 1.11) 0.71 0.85 (0.74,0.98) 0.03
 Simvastatin non-user 963 10,175 32,229 1.00 (ref. cat.)   1.00 (ref. cat.)  
 Simvastatin user 252 2,056 6,193 0.95 (0.83,1.09) 0.48 0.87 (0.75,1.02) 0.08
 Lipophilic non-user 961 10,168 32,212 1.00 (ref. cat.)   1.00 (ref. cat.)  
 Lipophilic user 254 2063 6,211 0.96 (0.83,1.10) 0.54 0.88 (0.76,1.02) 0.09
 Hydrophilic non-user 1077 11,161 35,181 1.00 (ref. cat.)   1.00 (ref. cat.)  
 Hydrophilic user 138 1,070 3,242 1.02 (0.85,1.21) 0.87 0.90 (0.75,1.09) 0.28
All-cause mortality
 Statin non-user 1,340 9,200 29,298 1.00 (ref. cat.)   1.00 (ref. cat.)  
 Statin user 691 3,031 9,125 0.96 (0.88,1.06) 0.41 0.75 (0.67,0.84) <0.001
 Simvastatin non-user 1,567 10,175 32,229 1.00 (ref. cat.)   1.00 (ref. cat.)  
 Simvastatin user 464 2,056 6,192 0.95 (0.86,1.06) 0.38 0.83 (0.74,0.92) 0.001
 Lipophilic non-user 1,564 10,168 32,212 1.00 (ref. cat.)   1.00 (ref. cat.)  
 Lipophilic user 467 2063 6211 0.96 (0.86,1.06) 0.42 0.83 (0.75,0.93) 0.001
 Hydrophilic non-user 1,788 11,161 35,181 1.00 (ref. cat.)   1.00 (ref. cat.)  
 Hydrophilic user 243 1,070 3,242 0.98 (0.86,1.12) 0.77 0.81 (0.70,0.93) 0.002
  1. aModel contains age, year of diagnosis, socioeconomic status, comorbidities (prior to diagnosis, including acute myocardial infarction, congestive heart disease, peripheral vascular disaese, cerebral vascular accident, pulmonary disease, peptic ulcer, liver disease, diabetes, renal disease) hormone replacement therapy use (in year prior to diagnosis), low-dose aspirin use and metformin (in year prior to diagnosis)