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Table 1 Characteristics of breast cancer patients by statin use

From: Statin use and breast cancer survival: a nationwide cohort study in Scotland

 

Statin use in the year prior to diagnosisa

 

Statin use in the year after diagnosisb

 

User

Non-user

 

User

Non-user

 

n

%

n

%

 

n

%

n

%

 
 

[n = 3,031]

[n = 9,200]

 

[n = 4,233]

[n = 10,907]

 

Year of diagnosis

 

 2009

     

861

23.8

2,811

24.4

<0.001

 2010

994

32.8

2,990

32.5

0.73

915

25.2

2,811

24.4

 

 2011

1,005

33.2

3,090

33.6

 

920

25.4

2,929

25.4

 

 2012

1,032

34.0

3,120

33.9

 

928

25.6

2,965

25.7

 

Age at diagnosis

 

 <50

69

2.3

2098

22.8

<0.01

93

2.4

2,741

23.9

<0.001

 50–59

322

10.6

2,516

27.3

 

447

12.3

3,246

28.2

 

 60–69

989

32.6

2,365

25.7

 

1,264

34.9

3,008

26.1

 

 70–79

911

30.1

1,242

13.5

 

1,082

29.9

1,508

13.1

 

 80–89

626

20.7

759

8.3

 

636

17.5

819

7.1

 

 ≥90

114

3.8

220

2.4

 

102

2.8

194

1.7

 

AJCC stage

 

 1

1086

35.8

3556

38.7

0.43

1400

38.6

4541

39.4

<0.001

 2

1053

34.7

3415

37.1

 

1290

35.6

4421

38.4

 

 3

353

11.6

1033

11.2

 

425

11.7

1337

11.6

 

 4

208

6.9

492

5.3

 

141

3.9

443

3.8

 

 Missing

331

10.9

704

7.7

 

368

10.2

774

6.7

 

Grade

 

 1

366

12.1

1089

11.8

<0.001

466

12.9

1363

11.8

0.003

 2

1335

44

4008

43.6

 

1647

45.4

5139

44.6

 

 3

900

29.7

3172

34.5

 

1130

31.2

4125

35.8

 

 Missing

430

14.2

931

10.1

 

381

10.5

889

7.7

 

Socioeconomic status

 

 1 (most deprived)

676

22.3

1419

15.4

<0.001

776

21.4

1,736

15.1

<0.001

 2

709

23.4

1682

18.3

 

825

22.8

2,089

18.1

 

 3

582

19.2

1,914

20.8

 

723

20.0

2,391

20.8

 

 4

587

19.4

2,025

22.0

 

703

19.4

2,582

22.4

 

 5 (least deprived)

477

15.7

2,159

23.5

 

597

16.5

2,717

23.6

 

Treatment (within 6 months)

 

 Surgery

2,163

71.4

7,322

79.6

<0.001

2,808

77.5

9,592

83.3

<0.001

 Radiotherapy

1,219

40.2

3,278

35.6

<0.001

1,486

41.0

4,080

35.4

<0.001

 Chemotherapy

546

18.0

3,566

38.7

<0.001

705

19.5

4,722

41.0

<0.001

Comorbidity prior to diagnosis

 

 Acute myocardial infarction

227

7.5

63

0.7

<0.001

246

6.8

59

0.5

<0.001

 Congestive heart failure

144

4.8

96

1.0

<0.001

149

4.1

76

0.7

<0.001

 Peripheral vascular disease

105

3.5

46

0.5

<0.001

114

3.1

50

0.4

<0.001

 Cerebral vascular accident

282

9.3

120

1.3

<0.001

287

7.9

116

1.0

<0.001

 Pulmonary disease

288

9.5

449

4.9

<0.001

305

8.4

499

4.3

<0.001

 Petptic ulcer

73

2.4

100

1.1

<0.001

86

2.4

119

1.0

<0.001

 Liver disease

8

0.3

13

0.1

0.34

8

0.2

17

0.1

0.16

 Diabetes

395

13.0

115

1.3

<0.001

422

11.6

129

1.1

<0.001

 Renal disease

101

3.3

94

1.0

<0.001

100

2.8

85

0.7

<0.001

Medication use in year after diagnosis

 Low-dose aspirinc

1,406

46.4

561

6.1

<0.001

1,617

44.6

737

6.4

<0.001

 Aromatase inhibitors

1,840

60.7

3,658

39.8

<0.001

2,258

62.3

4,550

39.5

<0.001

 Tamoxifen

850

28.0

4,038

43.9

<0.001

1,080

29.8

5,262

45.7

<0.001

 Metformin

1,201

33.1

1183

10.3

<0.001

440

14.5

98

1.1

<0.001

  1. aAnalysis includes breast cancer patients who have more than 1 year of records prior to diagnosis and excludes patients diagnosed 2009 for whom full medication records not available in the year prior to diagnosis. bPost-diagnostic statin use in the year after diagnosis among breast cancer patients who lived more than 1 year after diagnosis. cLow-dose aspirin use in year after diagnosis for statin use in year after diagnosis columns, low-dose aspirin use in year prior to diagnosis for statin use in year prior to diagnosis columns
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