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Table 1 Characteristics of breast cancer patients by statin use

From: Statin use and breast cancer survival: a nationwide cohort study in Scotland

  Statin use in the year prior to diagnosisa   Statin use in the year after diagnosisb
  User Non-user   User Non-user
  n % n %   n % n %  
  [n = 3,031] [n = 9,200]   [n = 4,233] [n = 10,907]  
Year of diagnosis  
 2009       861 23.8 2,811 24.4 <0.001
 2010 994 32.8 2,990 32.5 0.73 915 25.2 2,811 24.4  
 2011 1,005 33.2 3,090 33.6   920 25.4 2,929 25.4  
 2012 1,032 34.0 3,120 33.9   928 25.6 2,965 25.7  
Age at diagnosis  
 <50 69 2.3 2098 22.8 <0.01 93 2.4 2,741 23.9 <0.001
 50–59 322 10.6 2,516 27.3   447 12.3 3,246 28.2  
 60–69 989 32.6 2,365 25.7   1,264 34.9 3,008 26.1  
 70–79 911 30.1 1,242 13.5   1,082 29.9 1,508 13.1  
 80–89 626 20.7 759 8.3   636 17.5 819 7.1  
 ≥90 114 3.8 220 2.4   102 2.8 194 1.7  
AJCC stage  
 1 1086 35.8 3556 38.7 0.43 1400 38.6 4541 39.4 <0.001
 2 1053 34.7 3415 37.1   1290 35.6 4421 38.4  
 3 353 11.6 1033 11.2   425 11.7 1337 11.6  
 4 208 6.9 492 5.3   141 3.9 443 3.8  
 Missing 331 10.9 704 7.7   368 10.2 774 6.7  
Grade  
 1 366 12.1 1089 11.8 <0.001 466 12.9 1363 11.8 0.003
 2 1335 44 4008 43.6   1647 45.4 5139 44.6  
 3 900 29.7 3172 34.5   1130 31.2 4125 35.8  
 Missing 430 14.2 931 10.1   381 10.5 889 7.7  
Socioeconomic status  
 1 (most deprived) 676 22.3 1419 15.4 <0.001 776 21.4 1,736 15.1 <0.001
 2 709 23.4 1682 18.3   825 22.8 2,089 18.1  
 3 582 19.2 1,914 20.8   723 20.0 2,391 20.8  
 4 587 19.4 2,025 22.0   703 19.4 2,582 22.4  
 5 (least deprived) 477 15.7 2,159 23.5   597 16.5 2,717 23.6  
Treatment (within 6 months)  
 Surgery 2,163 71.4 7,322 79.6 <0.001 2,808 77.5 9,592 83.3 <0.001
 Radiotherapy 1,219 40.2 3,278 35.6 <0.001 1,486 41.0 4,080 35.4 <0.001
 Chemotherapy 546 18.0 3,566 38.7 <0.001 705 19.5 4,722 41.0 <0.001
Comorbidity prior to diagnosis  
 Acute myocardial infarction 227 7.5 63 0.7 <0.001 246 6.8 59 0.5 <0.001
 Congestive heart failure 144 4.8 96 1.0 <0.001 149 4.1 76 0.7 <0.001
 Peripheral vascular disease 105 3.5 46 0.5 <0.001 114 3.1 50 0.4 <0.001
 Cerebral vascular accident 282 9.3 120 1.3 <0.001 287 7.9 116 1.0 <0.001
 Pulmonary disease 288 9.5 449 4.9 <0.001 305 8.4 499 4.3 <0.001
 Petptic ulcer 73 2.4 100 1.1 <0.001 86 2.4 119 1.0 <0.001
 Liver disease 8 0.3 13 0.1 0.34 8 0.2 17 0.1 0.16
 Diabetes 395 13.0 115 1.3 <0.001 422 11.6 129 1.1 <0.001
 Renal disease 101 3.3 94 1.0 <0.001 100 2.8 85 0.7 <0.001
Medication use in year after diagnosis
 Low-dose aspirinc 1,406 46.4 561 6.1 <0.001 1,617 44.6 737 6.4 <0.001
 Aromatase inhibitors 1,840 60.7 3,658 39.8 <0.001 2,258 62.3 4,550 39.5 <0.001
 Tamoxifen 850 28.0 4,038 43.9 <0.001 1,080 29.8 5,262 45.7 <0.001
 Metformin 1,201 33.1 1183 10.3 <0.001 440 14.5 98 1.1 <0.001
  1. aAnalysis includes breast cancer patients who have more than 1 year of records prior to diagnosis and excludes patients diagnosed 2009 for whom full medication records not available in the year prior to diagnosis. bPost-diagnostic statin use in the year after diagnosis among breast cancer patients who lived more than 1 year after diagnosis. cLow-dose aspirin use in year after diagnosis for statin use in year after diagnosis columns, low-dose aspirin use in year prior to diagnosis for statin use in year prior to diagnosis columns