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Fig. 2 | BMC Cancer

Fig. 2

From: Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis

Fig. 2

Initial validation of two candidate biomarkers. a Western blot of ANXA4 and FLNA in the samples of NBM and paired BSCC and OSF, as well as their corresponding quantifications. b representative immunohistochemical staining for ANXA4. Negative expression of ANXA4 in NBM, brown cytoplasm staining limited to the spinous epithelial layer of OSF, and intensively staining of the cytoplasm in BSCC cell nest. c representative immunohistochemical staining for FLNA. Weak expression in NBM samples, brown cytoplasm staining limited to the lower spinous epithelial layer and basal cell layer of OSF, and intensively staining of the cytoplasm in BSCC cell

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