Fig. 2
From: Fibrillin-1 (FBN-1) a new marker of germ cell neoplasia in situ
Immunohistochemical detection of fibrillin-1 (FBN-1) and OCT3/4 expression in testicular tissues. a Germ cell neoplasia in situ (GCNIS), showed constant and strong cytoplasmic granular FBN-1 positivity (brown colour) with negativity in normal seminiferous tubules with spermiogenesis; (b) OCT3/4 expression in the same sample as in (a) with strong nuclear positivity in GCNIS (brown colour) and negativity in normal tubules. c Seminoma with focal strong cytoplasmic FBN-1 positivity; (d) Embryonal carcinoma with focal moderate to strong cytoplasmic FBN-1 positivity; (e) Yolk sac tumour with focal strong cytoplasmic FBN-1 positivity. Original magnification ×40/×400