Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation

Fig. 3

a Emodin/cisplatin co-treatment down-regulated the mRNA expression of MRP1, but had no effect on the MDR1, MRP2, ABCG2, CTR1, ATP7A, and ATP7B expression in T24 cells. b Emodin/cisplatin co-treatment down-regulated the mRNA expression of MRP1, but had no effect on the MDR1, MRP2, ABCG2, CTR1, ATP7A, and ATP7B expression in J82 cells. c Emodin/cisplatin co-treatment inhibited the protein expression of MRP1 but had no effect on the MDR1, MRP2, and ABCG2 expression in T24 cells. After transfected with MRP1 siRNA (d), the rate of cisplatin-mediated apoptosis reached 23.14 % ± 3.42 %, which was higher that of the control group (e). Each experiment was repeated three times

Back to article page