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Table 4 Univariateb and multivariate survivala analysis in type I and type II cancers for LINE1 DNA hypomethylation

From: Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers

   

Univariate

Multivariate

   

PFS

OS

PFS

OS

   

Months

CI 95 %

p value

Months

CI 9 5%

p value

HR

CI 95 %

p value

HR

CI 95 %

p value

Type I

LINE1 DNA hypomethylationc

Low

208.9

154.8-262.8

0.011*

197.62

148.2-247.1

0.006**

6.13

1.24-30.22

0.026*

6.82

1.53-30.39

0.012*

 

High

48.1

18.7-77.5

67.9

24.5-111.3

 

Grading

G1 VS G2-3

      

2.87

0.65-12.65

0.164

1.64

0.43-6.18

0.467

 

FIGO stage

I-II VS III-IV

      

1.98

0.21-18.69

0.549

1.09

0.07-16.16

0.949

 

Age

< o > median

      

0.61

0.11-3.27

0.566

3.84

1.09-13.52

0.036*

 

Residual disease

0 VS >0

      

5.16

2.76-9.64

<0.0001**

21.6

1.23-377.66

0.035*

Type II

LINE1 DNA hypomethylationc

low

51.4

15.0-87.8

0.791

86.10

38.7-133.5

0,878

      

high

42.7

15.7-69.8

68.97

38.9-98.9

  1. *Significant at the 0.05 level, **Significant at the 0.01 level, alog rank test, bCOX-regression analysis; cPUMR values
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BMC Cancer

ISSN: 1471-2407

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