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Table 4 Univariateb and multivariate survivala analysis in type I and type II cancers for LINE1 DNA hypomethylation

From: Evaluation of folate receptor 1 (FOLR1) mRNA expression, its specific promoter methylation and global DNA hypomethylation in type I and type II ovarian cancers

    Univariate Multivariate
    PFS OS PFS OS
    Months CI 95 % p value Months CI 9 5% p value HR CI 95 % p value HR CI 95 % p value
Type I LINE1 DNA hypomethylationc Low 208.9 154.8-262.8 0.011* 197.62 148.2-247.1 0.006** 6.13 1.24-30.22 0.026* 6.82 1.53-30.39 0.012*
  High 48.1 18.7-77.5 67.9 24.5-111.3
  Grading G1 VS G2-3        2.87 0.65-12.65 0.164 1.64 0.43-6.18 0.467
  FIGO stage I-II VS III-IV        1.98 0.21-18.69 0.549 1.09 0.07-16.16 0.949
  Age < o > median        0.61 0.11-3.27 0.566 3.84 1.09-13.52 0.036*
  Residual disease 0 VS >0        5.16 2.76-9.64 <0.0001** 21.6 1.23-377.66 0.035*
Type II LINE1 DNA hypomethylationc low 51.4 15.0-87.8 0.791 86.10 38.7-133.5 0,878       
high 42.7 15.7-69.8 68.97 38.9-98.9
  1. *Significant at the 0.05 level, **Significant at the 0.01 level, alog rank test, bCOX-regression analysis; cPUMR values