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Fig. 3 | BMC Cancer

Fig. 3

From: Pulmonary melanoma and “crazy paving” patterns in chest images: a case report and literature review

Fig. 3

Immunohistochemical (IHC) findings of computed tomography-guided fine-needle aspiration. Histopathological examination of biopsy shows perivascular and intra-alveolar accumulated pigmented cells containing melanin granules (hematoxylin and eosin, ×100) (a). Histopathological features of intra-alveolar atypical cell accumulation accompanied with interstitial thickenings; pleomorphic cells with atypia are pigmented deep brown and were diagnosed as melanocytes (hematoxylin and eosin, ×200) (b). IHC staining for Melan-A is positive (original magnification × 200) (c). All tumor cell cytoplasm and focal nuclei show positive IHC staining for HMB-45 (original magnification × 200) (d). IHC staining for S-100 is negative (original magnification × 200) (e)

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