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Table 1 Literature review of clinical and pathologic characteristics of lung adenocarcinomas with small cell carcinoma transformation

From: Case report: small cell transformation and metastasis to the breast in a patient with lung adenocarcinoma following maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitors

Case

Age

Sex

Smoking

Biopsy1

Genotype

Treatment

Biopsy2

Genotype

Reference

1

45

F

Never

Adeno

ND

Erlotinin

SCLC

19del

[9]

2

46

F

Never

Adeno

19del

Gefitinib

SCLC

19del

[10]

3

52

F

Never

Adeno

19del

Erlotinin

SCLC

19del

[11]

4

36

F

Never

Adeno

L858R

Geftinib

SCLC/Adeno

ND

[12]

5

67

F

ND

Adeno

L858R

EGFR-TKI

SCLC

L858R

[13]

6

54

F

ND

Adeno

19del

EGFR-TKI

SCLC

19del

[13]

7

56

F

ND

Adeno

L858R

EGFR-TKI

SCLC

L858R, PIK3CA

[13]

8

40

F

ND

Adeno

19del

EGFR-TKI

SCLC

19del

[13]

9

61

F

ND

Adeno

L858R

EGFR-TKI

SCLC

L858R

[13]

10

49

M

Yes

Adeno

L858R

Geftinib

SCLC

L858R

Our

  1. ND: not-determined; Adeno: adenocarcinoma; 19del: EGFR exon 19 deletion; L858R: point mutation of EGFR exon 21; SCLC: small cell lung cancer; EGFR-TKI: epidermal growth factor receptor tyrosine kinase inhibitor