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Table 2 Negative prognostic factors as they were evaluated by each study

From: Primary extramammary invasive Paget’s vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy?

Authors/Prognostic factors

Close or positive surgical margins

Dermal invasion

Lymph node metastasis

Adnexal involvement

Tumor size

Coexisting histology of adenocarcinoma or vulvar carcinoma

Perineal involvement

Stage

Multifocality

Besa et al. 1992 [6]

+

  

+

+

+

+

+

 

Luk et al. 2003 [7]

    

+

+

+

+

 

Son et al. 2005 [8]

    

+

+

   

Tanaka et al. 2009 [9]

+

+

+

      

Hata et al. 2011 [10]

+

+

+

      

Hata et al. 2012 [11]

 

+

+

 

+

    

Cai et al. 2013 [2]

+

+

+

+

 

+

  

+

Hata et al. 2014 [12]

 

+

+

 

+

    

Hata et al. 2015 [16]

 

+

+

 

+