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Table 2 Negative prognostic factors as they were evaluated by each study

From: Primary extramammary invasive Paget’s vulvar disease: what is the standard, what are the challenges and what is the future for radiotherapy?

Authors/Prognostic factors Close or positive surgical margins Dermal invasion Lymph node metastasis Adnexal involvement Tumor size Coexisting histology of adenocarcinoma or vulvar carcinoma Perineal involvement Stage Multifocality
Besa et al. 1992 [6] +    + + + + +  
Luk et al. 2003 [7]      + + + +  
Son et al. 2005 [8]      + +    
Tanaka et al. 2009 [9] + + +       
Hata et al. 2011 [10] + + +       
Hata et al. 2012 [11]   + +   +     
Cai et al. 2013 [2] + + + +   +    +
Hata et al. 2014 [12]   + +   +     
Hata et al. 2015 [16]   + +   +