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Fig. 6 | BMC Cancer

Fig. 6

From: The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells

Fig. 6

Immunohistochemical localization of vitronectin in human NSCLC tumors. (a) Low-magnification image of a representative tumor section of squamous cell carcinoma. Vitronectin expression is seen surrounding blood vessels (black arrows, box 1), in the tumor-stroma interface (open arrow, box 2), and associated with necrotic tissue (open arrowhead). Scale bar = 250 μm. (b) High-magnification image of box 1 in panel a. Vitronectin positive staining in a collapsed small artery (arrow on right) and an arteriole (arrow on left) located in the stroma. (c) Highmagnification image of box 2 in panel a. Vitronectin-positive staining in the interstitial space between tumor cells (T) and adjacent normal stroma (S). Scale bar in (b) and (c) = 50 μm

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