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Fig. 4 | BMC Cancer

Fig. 4

From: The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells

Fig. 4

FnIII-1c induces Akt phosphorylation in NCI-H460 cells. NCI-H460 cells were treated with various concentrations of FnIII-1c for 1 h (a) or with 10 μM FnIII-1c for increasing lengths of time (b). NCI-H460 cells were treated with the control modules, FnIII-10n (c) or FnIII-13 (d), at the designated concentrations for 1 h. PBS served as control. Cell lysates were analyzed by western blotting for phosphorylated Akt (pS473Akt). GAPDH served as loading control

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