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Fig. 1 | BMC Cancer

Fig. 1

From: The fibronectin III-1 domain activates a PI3-Kinase/Akt signaling pathway leading to αvβ5 integrin activation and TRAIL resistance in human lung cancer cells

Fig. 1

NCI-H460 cells are sensitive to TRAIL-induced apoptosis. Whole cell lysates were collected from NCI-H460 cells treated with various concentrations of TRAIL for 1 h (a) or 100 ng/ml of TRAIL for the indicated time (b). Lysates were subjected to western blot analysis for cleaved caspase 8 then stripped and reprobed for GAPDH as a loading control. c NCI-H460 cells were treated with 50 ng/ml TRAIL for the indicated times and apoptosis was assessed by TUNEL assay. Cells were counterstained with Hoechst 33342 dye to denote nuclei. PBS served as control. Bar = 50 μm

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