Fig. 2From: Pazolimus: pazopanib plus sirolimus following progression on pazopanib, a retrospective case series analysisCompensatory VEGF overexpression. Initiation of pazopanib leads to a decrease in angiogenesis and development of hypoxia. Hypoxia causes an increase in HIF-1a levels, leading to increased production of target genes including VEGF. mTOR inhibition may stop this compensatory increaseBack to article page