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Fig. 2 | BMC Cancer

Fig. 2

From: Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway

Fig. 2

NF-kB induced tumor growth in HOC-7 cells. a HOC-7-IkBαM cells displayed dramatically increase of cell proliferation compare with parental cells. b colony formation of HOC-7 transgenic cells and parental cells. c In vivo, NF-kB induced tumor growth both in SKOV3 and HOC-7 xenograft nude mice“ to ”Fig. 2. NF-kB induced tumor growth in HOC-7 cells. a HOC-7-IkBαM cells displayed dramatically increase of cell proliferation compare with parental cells. b In vivo, NF-kB induced tumor growth both in SKOV3 and HOC-7 xenograft nude mice (c) BCL-xl is the key protein involved in the phenotypic shift. d colony formation of HOC-7 transgenic cells and parental cells. e Data represent the mean ± standard error of the mean (SEM) percentage of the number of invasion cells compared to the control; *p < 0.05, n = 3. Error bars = 95 % confidence intervals. f NF-kB - induced apoptosis correlated with MAPKs pathway and apoptosis pathway in vivo. The western blot data from the mice tumors showed that expression of p-MEK increased in mice tissue carrying HOC-7 IkBαM compare with those carrying HOC-7 vector, while the expression of p-ERK instead of p-MEK decreased in mice tissue carrying SKOV3 IkBαM compare with those carrying SKOV3 vector. Generally, NF-kB induced apoptosis in a MAPKs dependent pathway in vivo

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