TY - JOUR AU - Jansen, Femke AU - Cnossen, Ingrid C. AU - Eerenstein, Simone E. J. AU - Coupé, Veerle M. H. AU - Witte, Birgit I. AU - van Uden-Kraan, Cornelia F. AU - Doornaert, Patricia AU - Braunius, Weibel W. AU - De Bree, Remco AU - Hardillo, José A. U. AU - Honings, Jimmie AU - Halmos, György B. AU - Leemans, C. René AU - Verdonck-de Leeuw, Irma M. PY - 2016 DA - 2016/08/02 TI - Effectiveness and cost-utility of a guided self-help exercise program for patients treated with total laryngectomy: protocol of a multi-center randomized controlled trial JO - BMC Cancer SP - 580 VL - 16 IS - 1 AB - Total laryngectomy with or without adjuvant (chemo)radiation often induces speech, swallowing and neck and shoulder problems. Speech, swallowing and shoulder exercises may prevent or diminish these problems. The aim of the present paper is to describe the study, which is designed to investigate the effectiveness and cost-utility of a guided self-help exercise program built into the application “In Tune without Cords” among patients treated with total laryngectomy. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-016-2613-6 DO - 10.1186/s12885-016-2613-6 ID - Jansen2016 ER -