Fig. 1

Clustering of unselected breast tumors. a The biomarker variables ER, PgR, PIK3CA, TP53, HER2, PTEN, EGFR, and CK5/14 were used to hierarchically cluster 116 breast tumors. Biomarker data are colored such that red = positive, black = negative, green = mutant (TP53) or lost (INPP4B, PTEN; asterix denotes PTEN mutation), and grey = missing data. b Below the heatmap are additional clinicopathological annotations not used to generate the clustered heatmap: Ki67, S-phase fraction (SPF), histological grade, PTEN-loss signature status, and intrinsic molecular subtype by gene expression profilling. For each annotation, color key is shown to the right (grey = missing data). SP = signature present; SA = signature absent; NC = not classified