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Table 2 Apoptosis associated proteins change in group BF + GCV

From: Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors

Gene PBS + GCV BF/GCV Ratio
Bad 335.83 982.79 2.93
Bax 516.54 1567.29a 3.03
Bim 192.61 1488.21 7.73
Bcl-2 192.61 968.65 a 5.03
Bcl-w 192.61 1342.08 6.97
IGF-1 192.61 984.35 5.11
IGF-2 192.61 997.97 5.18
Caspase 3 192.61 1262.99 6.56
Caspase 8 192.61 1708.19 8.87
HtrA2 192.61 1314.83 6.83
Fas 538.63 1201.19 2.23
FasL 521.06 1154.57 2.22
P53 489.92 1175.53 2.40
P27 620.96 1405.44 2.26
  1. The boldface letters were anti-apoptosis proteins and the others were apoptosis proteins
  2. aThe ratio of Bax/Bcl-2 is 0.60
  3. Up-regulation of fourteen differential proteins expression was more than doubled in the BF + GCV group unlike the expression in the PBS + GCV group. To summarize, the anti-apoptosis proteins were increased more than 5.0-fold. The total ratio of pro-apoptosis to anti-apoptosis proteins was 2.02-fold and the ratio of Bax/Bcl-2 was 0.60. The typical mitochondrial control signal molecule, Cytochrome C (Cyto C), was not significantly changed in group BF + GCV. The results suggested that bifidobacterium itself (not GCV) induced cancer cell apoptosis via Fas/FasL signaling pathway without mitochondrial alteration and up-regulated P53 expression