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Fig. 3 | BMC Cancer

Fig. 3

From: Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors

Fig. 3

BF-rTK + GCV regulates colo320 tumor xenograft tissues apoptosis, up- regulates FADD, APAF-1 and cleaved caspase-3, and down- regulates XIAP. H&E (hematoxylin-eosin staining) and immunohistochemistry were performed using the specific antibody of cleaved caspase-3, apaf-1, FADD and XIAP antibody and the xenograft tumor tissues treated with PBS, GCV, BF, BF + GCV and BF-rTK + GCV (200×, n = 3). a Representative histologic sections of H&E staining. The yellow color showed positively stained cells by cleaved caspase-3, apaf-1, FADD and XIAP antibody. b, c, d and e IOD SUM of positive cells was compared among PBS, GCV, BF, BF + GCV and BF-rTK + GCV mice. Data were given as means and 95 % confidence intervals. Asterisks indicate data that were significantly different from PBS, GCV groups and BF, BF + GCV groups, or both BF, BF + GCV groups and BF-rTK + GCV groups (*P < 0.05 statistically significant when comparing treated versus control)

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