Table 1 Baselines characteristics of the sample of the study
Baseline characteristics | n° | % | DSU (%) | BMTU (%) | |
|---|---|---|---|---|---|
Patient n° | 45 | 100 | 7 (15.5) | 38 (84.4) | |
Gender | F | 15 | 33.3 | 5 (16.3) | 13 (86.7) |
M | 30 | 66.6 | 5 (16.7) | 25 (83.3) | |
Age | <1 years | 2 | 15.5 | 15.5 1 (50.0) | 1 (50.0) |
1–5 years | 15 | 24.4 | 2 (13.3) | 13 (86.7) | |
6–10 years | 13 | 28.8 | 1 (7.8) | 12 (92.3) | |
10–18 years | 15 | 31.1 | 3 (20.0) | 12 (80.0) | |
Primary disease | AL | 27 | 60.0 | 4 (14.8) | 23 (85.2) |
Hemoglobinopathy | 1 | 2.2 | - | 1 (100) | |
Inherited disease | 6 | 13.3 | 1 (16.7) | 5 (83.3) | |
MDS | 10 | 22.2 | 2 (20.0) | 8 (80.0) | |
Solid tumor | 1 | 2.2 | - | 1 (100) | |
Number of HSCT | 1 | 37 | 82.1 | 6 (16.3) | 31 (83.7) |
2 | 5 | 11.1 | 1 (20.0) | 4 (80.0) | |
3 | 2 | 4.4 | - | 2 (100) | |
Type of Donor | Haploidentical | 6 | 13.3 | 4 (66.7) | 2 (33.3) |
Matched related | 18 | 40.0 | 2 (11.1) | 16 (88.9) | |
Matched unrelated | 21 | 86.6 | 1 (4.8) | 20 (95.2) | |
Conditioning regimen | Myeloablative | 39 | 86.6 | 7 (17.9) | 32 (82.1) |
RIC | 6 | 13.3 | - | 6 (100) | |
Gilbert syndrome | Yes | 9 | 20.0 | 1 (11.1) | 8 (88.9) |
No | 36 | 80.0 | 6 (16.6) | 30 (83.3) | |
Pre transplant hepatopathy | No | 18 | 40.0 | 1 (5.5) | 17 (94.4) |
Acquired metabolic disorders | 1 | 2.2 | - | 1 (100) | |
Drug Hepatotoxicity | 1 | 2.2 | - | 1 (100) | |
Inherited metabolic disease | 2 | 4.4 | 1 (50.0) | 1 (50.0) | |
Iron overload | 21 | 46.6 | 4 (19.0) | 17 (80.9) | |
Viral hepatitis | 2 | 4.4 | 1 (50.0) | 1 (50.0) | |
MRI quantification LIC | Patients undergoing MRI | 42 | 93.3 | 4 (9.5) | 38 (90.5) |
Normal liver | 4 | 9.5 | - | 4 (100) | |
Slight overload | 16 | 38.0 | - | 16 (100) | |
Moderate overload | 8 | 19.0 | 2 (25.0) | 6 (75.0) | |
Major overload | 14 | 33.3 | 2 (14.3) | 12 (85.7) | |
Obesity (BMI >30) | 6 | 13.3 | 2 (33.3) | 4 (66.7) |