Fig. 4

Serum lipocalin-2 (LCN2) and matrix metalloproteinase-9 (MMP9) levels during neoadjuvant therapy. Array fluorescence intensities relative to the individual patient’s baseline values following induction neoadjuvant chemotherapy (post-NACT; n = 50 for LCN2 and n = 61 for MMP9) and sequential chemoradiotherapy (post-CRT; n = 48 for LCN2 and n = 57 for MMP9) and at treatment evaluation (n =50 for LCN2 and n =54 for MMP9); lines, median group values; *p < 0.01; **p < 0.001; ***p < 0.0001