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Fig. 1 | BMC Cancer

Fig. 1

From: Pro-survival responses to the dual inhibition of anti-apoptotic Bcl-2 family proteins and mTOR-mediated signaling in hypoxic colorectal carcinoma cells

Fig. 1

Cell viability in hypoxic colorectal carcinoma (CRC) cell lines. Fourteen CRC cell lines were treated for 24 h with ABT-737 (inhibitor of anti-apoptotic Bcl-2 family proteins; 10 μM), AZD8055 (mTOR inhibitor; 10 μM), or combo-Rx (10 μM of both compounds in combination) under hypoxic conditions. Cell viability (measured by the MTS assay) value for each condition relative to the corresponding control cell value is shown as mean ± SD. Statistically significant changes are indicated (asterisk, p < 0.05; cross, p < 0.01; circle, p < 0.001)

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