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Fig. 2 | BMC Cancer

Fig. 2

From: Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells

Fig. 2

SSd inhibited the collagen I and III expression and secretion in HSC-T6 and LX-2 cells. (a and b) HSC-T6 and LX-2 cells were treated with or without SSd (1 μM) for 0, 24, 48 and 72 h. The total cellular protein content was extracted to measure the collagen type I and type III expression by western blotting. The fold change in protein expression is expressed as a ratio calculated by dividing the specific protein band density by the β-actin band density. The supernatant was collected to measure the secreted collagen type I (c) and collagen type III (d) by ELISA. *P < 0.01 versus time zero or the control group

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