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Fig. 6 | BMC Cancer

Fig. 6

From: Heat shock protein 70–2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth

Fig. 6

HSP70-2 gene silencing resulted in reduced tumor growth of COLO205 xenograft. a Representative images of resected tumor show significant reduction in tumor size treated with HSP70-2 shRNA4 as compared to control NC shRNA treated tumor. b Graph represents reduced tumor growth in HSP70-2 shRNA4 treated mice as compared to control NC shRNA treated mice. c Histogram depicts decreased tumor weight in HSP70-2 shRNA4 treated mice as compared to control NC shRNA treated mice. d Western Blot analysis shows reduced HSP70-2 protein and PCNA expression in HSP70-2 shRNA4 treated mice as compared to control NC shRNA treated mice. β-actin was used as a loading control. e IHC analysis of tumor sections show reduced HSP70-2 (middle panel) and PCNA (right panel) expression in HSP70-2 shRNA4 treated mice as compared to control NC shRNA treated mice. Left panel shows cytostructure by H&E staining. Representative histogram shows significant reduced HSP70-2 and PCNA expression in HSP70-2 shRNA4 treated mice as compared to control NC shRNA treated mice. *p < 0.0001, statistically significant. Original magnification x200, objective x20. Scale bar: 100 μm

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