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Table 4 Univariate analyses and multivariate analysis of factors associated with relapse-free survival for ESCC patients (NESCC = 288)

From: Single nucleotide polymorphism rs13042395 in the SLC52A3 gene as a biomarker for regional lymph node metastasis and relapse-free survival of esophageal squamous cell carcinoma patients

Variables HR 95 % CI for HR P
Lower Upper
Univariate analyses
 Gender
  Female 1.00 Reference  
  Male 1.12 0.75 1.66 0.58
Age (years) 0.99 0.97 1.01 0.42
rs13042395
  CC 1.00 Reference  
  CT 1.05 0.70 1.57 0.82
  TT 0.62 0.36 1.06 0.08
  CT + TT 0.90 0.61 1.33 0.60
  CC + CT 1.00 Reference  
  TT 0.60 0.38 0.96 0.03
rs3746803
  GG 1.00 Reference  
  GA + AA 1.23 0.72 2.12 0.44
Tumor size (cm)
  ≤3 1.00 Reference  
  4–5 1.48 0.97 2.27 0.07
  ≥6 1.40 0.85 2.31 0.18
   P trend     0.18
Depth of tumor invasion
  Tis + T1 1.00 Reference  
  T2 5.42 1.21 24.24 0.03
  T3 10.78 2.66 43.70 <0.001
  T4 4.68 0.42 51.70 0.21
   P trend     0.001
Regional lymph node metastasis
  N0 1.00 Reference  
  N1 2.63 1.74 3.98 <0.001
  N2 3.73 2.24 6.23 <0.001
  N3 3.46 1.74 6.91 <0.001
   P trend     <0.001
Tumor location
  Upper thoracic 1.00 Reference  
  Middle thoracic 0.63 0.34 1.16 0.14
  Lower thoracic 0.72 0.38 1.36 0.31
   P trend     0.31
TNM classification
  0 + I 1.00 Reference  
  II 5.83 1.81 18.76 0.003
  III 14.21 4.47 45.17 <0.001
   P trend     <0.001
Radiotherapy after surgery
  No 1.00 Reference  
  Yes 2.12 1.48 3.03 <0.001
Chemotherapy after surgery
  No 1.00 Reference  
  Yes 1.69 1.17 2.44 0.005
Multivariate analysis
rs13042395
  CC + CT 1.00 Reference  
  TT 0.62 0.38 0.99 0.046
Depth of tumor invasion
  Tis + T1 1.00 Reference  
  T2 4.23 0.94 19.11 0.06
  T3 6.37 1.54 26.40 0.01
  T4 1.47 0.13 16.94 0.76
   P trend     0.001
Regional lymph node metastasis
  N0 1.00 Reference  
  N1 2.06 1.36 3.13 <0.001
  N2 2.88 1.70 4.86 0.001
  N3 2.08 1.01 4.30 <0.001
   P trend     0.047
Radiotherapy after surgery
  No 1.00 Reference  
  Yes 1.68 1.16 2.43 0.006
  1. All associations are significant at P < 0.05
  2. ESCC esophageal squamous cell carcinomas, HR hazard ratio, 95 % CI 95 % confidence interval