Skip to main content

Table 4 Univariate analyses and multivariate analysis of factors associated with relapse-free survival for ESCC patients (NESCC = 288)

From: Single nucleotide polymorphism rs13042395 in the SLC52A3 gene as a biomarker for regional lymph node metastasis and relapse-free survival of esophageal squamous cell carcinoma patients

Variables

HR

95 % CI for HR

P

Lower

Upper

Univariate analyses

 Gender

  Female

1.00

Reference

 

  Male

1.12

0.75

1.66

0.58

Age (years)

0.99

0.97

1.01

0.42

rs13042395

  CC

1.00

Reference

 

  CT

1.05

0.70

1.57

0.82

  TT

0.62

0.36

1.06

0.08

  CT + TT

0.90

0.61

1.33

0.60

  CC + CT

1.00

Reference

 

  TT

0.60

0.38

0.96

0.03

rs3746803

  GG

1.00

Reference

 

  GA + AA

1.23

0.72

2.12

0.44

Tumor size (cm)

  ≤3

1.00

Reference

 

  4–5

1.48

0.97

2.27

0.07

  ≥6

1.40

0.85

2.31

0.18

   P trend

   

0.18

Depth of tumor invasion

  Tis + T1

1.00

Reference

 

  T2

5.42

1.21

24.24

0.03

  T3

10.78

2.66

43.70

<0.001

  T4

4.68

0.42

51.70

0.21

   P trend

   

0.001

Regional lymph node metastasis

  N0

1.00

Reference

 

  N1

2.63

1.74

3.98

<0.001

  N2

3.73

2.24

6.23

<0.001

  N3

3.46

1.74

6.91

<0.001

   P trend

   

<0.001

Tumor location

  Upper thoracic

1.00

Reference

 

  Middle thoracic

0.63

0.34

1.16

0.14

  Lower thoracic

0.72

0.38

1.36

0.31

   P trend

   

0.31

TNM classification

  0 + I

1.00

Reference

 

  II

5.83

1.81

18.76

0.003

  III

14.21

4.47

45.17

<0.001

   P trend

   

<0.001

Radiotherapy after surgery

  No

1.00

Reference

 

  Yes

2.12

1.48

3.03

<0.001

Chemotherapy after surgery

  No

1.00

Reference

 

  Yes

1.69

1.17

2.44

0.005

Multivariate analysis

rs13042395

  CC + CT

1.00

Reference

 

  TT

0.62

0.38

0.99

0.046

Depth of tumor invasion

  Tis + T1

1.00

Reference

 

  T2

4.23

0.94

19.11

0.06

  T3

6.37

1.54

26.40

0.01

  T4

1.47

0.13

16.94

0.76

   P trend

   

0.001

Regional lymph node metastasis

  N0

1.00

Reference

 

  N1

2.06

1.36

3.13

<0.001

  N2

2.88

1.70

4.86

0.001

  N3

2.08

1.01

4.30

<0.001

   P trend

   

0.047

Radiotherapy after surgery

  No

1.00

Reference

 

  Yes

1.68

1.16

2.43

0.006

  1. All associations are significant at P < 0.05
  2. ESCC esophageal squamous cell carcinomas, HR hazard ratio, 95 % CI 95 % confidence interval