Variables | HR | 95Â % CI for HR | P | |
---|---|---|---|---|
Lower | Upper | |||
Univariate analyses | ||||
 Gender | ||||
  Female | 1.00 | Reference |  | |
  Male | 1.12 | 0.75 | 1.66 | 0.58 |
Age (years) | 0.99 | 0.97 | 1.01 | 0.42 |
rs13042395 | ||||
  CC | 1.00 | Reference |  | |
  CT | 1.05 | 0.70 | 1.57 | 0.82 |
  TT | 0.62 | 0.36 | 1.06 | 0.08 |
  CT + TT | 0.90 | 0.61 | 1.33 | 0.60 |
  CC + CT | 1.00 | Reference |  | |
  TT | 0.60 | 0.38 | 0.96 | 0.03 |
rs3746803 | ||||
  GG | 1.00 | Reference |  | |
  GA + AA | 1.23 | 0.72 | 2.12 | 0.44 |
Tumor size (cm) | ||||
  ≤3 | 1.00 | Reference |  | |
  4–5 | 1.48 | 0.97 | 2.27 | 0.07 |
  ≥6 | 1.40 | 0.85 | 2.31 | 0.18 |
   P trend |  |  |  | 0.18 |
Depth of tumor invasion | ||||
  Tis + T1 | 1.00 | Reference |  | |
  T2 | 5.42 | 1.21 | 24.24 | 0.03 |
  T3 | 10.78 | 2.66 | 43.70 | <0.001 |
  T4 | 4.68 | 0.42 | 51.70 | 0.21 |
   P trend |  |  |  | 0.001 |
Regional lymph node metastasis | ||||
  N0 | 1.00 | Reference |  | |
  N1 | 2.63 | 1.74 | 3.98 | <0.001 |
  N2 | 3.73 | 2.24 | 6.23 | <0.001 |
  N3 | 3.46 | 1.74 | 6.91 | <0.001 |
   P trend |  |  |  | <0.001 |
Tumor location | ||||
  Upper thoracic | 1.00 | Reference |  | |
  Middle thoracic | 0.63 | 0.34 | 1.16 | 0.14 |
  Lower thoracic | 0.72 | 0.38 | 1.36 | 0.31 |
   P trend |  |  |  | 0.31 |
TNM classification | ||||
  0 + I | 1.00 | Reference |  | |
  II | 5.83 | 1.81 | 18.76 | 0.003 |
  III | 14.21 | 4.47 | 45.17 | <0.001 |
   P trend |  |  |  | <0.001 |
Radiotherapy after surgery | ||||
  No | 1.00 | Reference |  | |
  Yes | 2.12 | 1.48 | 3.03 | <0.001 |
Chemotherapy after surgery | ||||
  No | 1.00 | Reference |  | |
  Yes | 1.69 | 1.17 | 2.44 | 0.005 |
Multivariate analysis | ||||
rs13042395 | ||||
  CC + CT | 1.00 | Reference |  | |
  TT | 0.62 | 0.38 | 0.99 | 0.046 |
Depth of tumor invasion | ||||
  Tis + T1 | 1.00 | Reference |  | |
  T2 | 4.23 | 0.94 | 19.11 | 0.06 |
  T3 | 6.37 | 1.54 | 26.40 | 0.01 |
  T4 | 1.47 | 0.13 | 16.94 | 0.76 |
   P trend |  |  |  | 0.001 |
Regional lymph node metastasis | ||||
  N0 | 1.00 | Reference |  | |
  N1 | 2.06 | 1.36 | 3.13 | <0.001 |
  N2 | 2.88 | 1.70 | 4.86 | 0.001 |
  N3 | 2.08 | 1.01 | 4.30 | <0.001 |
   P trend |  |  |  | 0.047 |
Radiotherapy after surgery | ||||
  No | 1.00 | Reference |  | |
  Yes | 1.68 | 1.16 | 2.43 | 0.006 |