Single nucleotide polymorphism rs13042395 in the SLC52A3 gene as a biomarker for regional lymph node metastasis and relapse-free survival of esophageal squamous cell carcinoma patients

Table 3 Association between SNPs in SLC52A3 and clinical characteristics of ESCC in the Chinese population (N_ESCC = 343)

Genotype	Tumor size (≤3 cm/4–5 cm/≥6 cm)		Depth of tumor invasion ((Tis + T1)/T2/T3/T4)		Regional lymph node metastasis (N0/N1/N2/N3)		Distant metastasis (M0/M1)		TNM classification ((0 + I)/II/III/IV)
Genotype	OR (95 % CI)	P	OR (95 % CI)	P	OR (95 % CI)	P	OR (95 % CI)	P	OR (95 % CI)	P
rs13042395
CC	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
CT	1.17 (0.73–1.86)	0.53	0.90 (0.52–1.55)	0.71	0.83 (0.52–1.33)	0.45	0.83 (0.14–5.04)	0.84	0.79 (0.41–1.26)	0.33
TT	1.18 (0.67–2.06)	0.57	0.82 (0.43–1.56)	0.55	0.55 (0.31–0.98)	0.04	0.59 (0.05–6.63)	0.67	0.72 (0.49–1.27)	0.25
CT + TT	1.17 (0.75–1.82)	0.49	0.88 (0.52–1.46)	0.61	0.73 (0.47–1.14)	0.16	0.75 (0.14–4.17)	0.74	0.76 (0.49–1.20)	0.24
CC + CT	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
TT	1.07 (0.67–1.70)	0.79	0.88 (0.52–1.50)	0.63	0.62 (0.38–1.01)	0.06	0.66 (0.08–5.77)	0.71	0.84 (0.52–1.34)	0.46
rs3746803
GG	1.00 (Reference)		1.00 (Reference)		1.00 (Reference)		1.00 (Reference)		1.00 (Reference)
GA + AA	1.1 (0.57–2.09)	0.78	1.4 (0.65–3.00)	0.39	1.06 (0.55–2.03)	0.87	1.73 (0.20–15.02)	0.62	1.3 (0.67–2.51)	0.43

All associations are significant at P < 0.05
SNP single nucleotide polymorphism, ESCC esophageal squamous cell carcinoma, OR odds ratio, 95 % CI 95 % confidence interval

ISSN: 1471-2407