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Table 3 Association between SNPs in SLC52A3 and clinical characteristics of ESCC in the Chinese population (NESCC = 343)

From: Single nucleotide polymorphism rs13042395 in the SLC52A3 gene as a biomarker for regional lymph node metastasis and relapse-free survival of esophageal squamous cell carcinoma patients

Genotype Tumor size (≤3 cm/4–5 cm/≥6 cm) Depth of tumor invasion ((Tis + T1)/T2/T3/T4) Regional lymph node metastasis (N0/N1/N2/N3) Distant metastasis (M0/M1) TNM classification ((0 + I)/II/III/IV)
OR (95 % CI) P OR (95 % CI) P OR (95 % CI) P OR (95 % CI) P OR (95 % CI) P
rs13042395
 CC 1.00 (Reference)   1.00 (Reference)   1.00 (Reference)   1.00 (Reference)   1.00 (Reference)  
 CT 1.17 (0.73–1.86) 0.53 0.90 (0.52–1.55) 0.71 0.83 (0.52–1.33) 0.45 0.83 (0.14–5.04) 0.84 0.79 (0.41–1.26) 0.33
 TT 1.18 (0.67–2.06) 0.57 0.82 (0.43–1.56) 0.55 0.55 (0.31–0.98) 0.04 0.59 (0.05–6.63) 0.67 0.72 (0.49–1.27) 0.25
 CT + TT 1.17 (0.75–1.82) 0.49 0.88 (0.52–1.46) 0.61 0.73 (0.47–1.14) 0.16 0.75 (0.14–4.17) 0.74 0.76 (0.49–1.20) 0.24
 CC + CT 1.00 (Reference)   1.00 (Reference)   1.00 (Reference)   1.00 (Reference)   1.00 (Reference)  
 TT 1.07 (0.67–1.70) 0.79 0.88 (0.52–1.50) 0.63 0.62 (0.38–1.01) 0.06 0.66 (0.08–5.77) 0.71 0.84 (0.52–1.34) 0.46
rs3746803
 GG 1.00 (Reference)   1.00 (Reference)   1.00 (Reference)   1.00 (Reference)   1.00 (Reference)  
 GA + AA 1.1 (0.57–2.09) 0.78 1.4 (0.65–3.00) 0.39 1.06 (0.55–2.03) 0.87 1.73 (0.20–15.02) 0.62 1.3 (0.67–2.51) 0.43
  1. All associations are significant at P < 0.05
  2. SNP single nucleotide polymorphism, ESCC esophageal squamous cell carcinoma, OR odds ratio, 95 % CI 95 % confidence interval