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Table 4 Comparison of FISH and IHC in ROS1 rearrangement detection

From: Comparison of detection methods and follow-up study on the tyrosine kinase inhibitors therapy in non-small cell lung cancer patients with ROS1 fusion rearrangement

  FISH ROS1 fusion positive FISH ROS1 fusion negative P. Kappa Value
IHC ROS1 2-3+ 10 1 < 0.01a 0.950
IHC ROS1-, 1+ 0 227   
IHC extent ≥ 60 % 10 9 < 0.01a 0.672
IHC extent < 60 % 0 219   
IHC H-score ≥ 150 10 0 < 0.01a 1.000
IHC H-score < 150 0 228   
  1. aFisher exact test