Comparison of detection methods and follow-up study on the tyrosine kinase inhibitors therapy in non-small cell lung cancer patients with ROS1 fusion rearrangement

Table 1 Characteristic of included cases

Characteristic		Total	Surgery resection	Biopsy	ROS1 rearrangement	ROS1 non–rearrangement	P.
No.		238	215	23	10	228
Age							0.114^a
	>61	109	101	8	2	107
	≤61	129	114	15	8	121
Gender							0.118^a
	Male	131	118	13	3	128
	Female	107	97	10	7	100
Smoking history							0.792^a
	Smoker	51	48	3	3	48
	Non–smoker	158	140	18	6	152
	Previous smoker	29	27	2	1	28
Histopathology							1.000^a
	ADC	216 (8)^b	195 (6)^b	21 (2)^b	10	206 (8)^b
	SCC	11	9	2	0	11
	ASC	2	2	–	0	2
	LCLC	9 (1) ^b	9 (1) ^b	–	0	9 (1) ^b
Adenocarcinoma subtypes (predominant pattern)^c							0.207^a
	Lepidic	17	17	–	2	15
	Acinar	105	105	–	4	101
	Papillary	33	33	–	3	30
	Micropapillary	16	16	–	2	14
	Solid	20	20	–	0	20
	Invasive mucinous adenocarcinoma	8	8	–	1	7
	Fetal	1	1		0	1
TMN stage^d							0.175^a
	I	114	114	0	6	108
	II	30	29	1	1	29
	III	55(IIIb:10)	53	2	0	55
	IV	38	18	20	3	35
Sica grading^e							0.871^a
	Score 2	6	6	-	0	6
	Score 3	48	48	-	3	45
	Score 4	48	48	-	1	47
	Score 5	69	69	-	4	65
	Score 6	10	10	-	0	10
WHO grading^e							0.597^a
	Low grade	17	17	-	1	16
	Intermediate grade	126	126	-	5	121
	High grade	38	38	-	2	36
Another gene status							–
	ALK	228 (12)^f	206 (11)^f	22 (1)^f	0	228
	EGFR	163 (87)^f	141 (78)^f	22 (9)^f	0	163
	exon 19 deletion	37	33	4	0	37
	L858R	48^g	44^g	4	0	48
	L861Q	1	1	0	0	1
	exon 20 S768I	2^g	1^g	1	0	2
	KRAS	153 (13)^f	136 (11)^f	17 (2)^f	0	153
	Gly12Asp	3	3	0	0	3
	Gly12Cys	4	4	0	0	4
	Gly12Val	4	4	0	0	4
	Gly12Ala	1	0	1	0	1
	Gly12Ser	1	0	1	0	1

Abbreviations: ADC Adenocarcinoma, SCC Squamous cell carcinoma, ASC Adenosquamous carcinoma, LCLC Large–cell lung carcinoma, ALK anaplastic lymphoma receptor tyrosine kinase, EGFR epidermal growth factor receptor, KRAS Kirsten rat sarcoma viral oncogene homolog
^aFisher exact test
^bMetastasis cases
^cTotal 190 resected adenocarcinoma with 200 predominant patterns were discussed. Some cases were including more than one predominant patterns
^dA case was diagnosed as stage 0
^eTotal 181 resected adenocarcinoma have been analyzed, excluding variant subtypes
^fThe cases with ALK rearrangement, EGFR mutation or KRAS mutation
^gThere was a case harboring both exon 21 L858R and exon 20 S768I mutation

ISSN: 1471-2407