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Table 1 Characteristic of included cases

From: Comparison of detection methods and follow-up study on the tyrosine kinase inhibitors therapy in non-small cell lung cancer patients with ROS1 fusion rearrangement

Characteristic   Total Surgery resection Biopsy ROS1 rearrangement ROS1 non–rearrangement P.
No.   238 215 23 10 228  
Age        0.114a
>61 109 101 8 2 107  
≤61 129 114 15 8 121  
Gender        0.118a
Male 131 118 13 3 128  
Female 107 97 10 7 100  
Smoking history        0.792a
Smoker 51 48 3 3 48  
Non–smoker 158 140 18 6 152  
Previous smoker 29 27 2 1 28  
Histopathology        1.000a
ADC 216 (8)b 195 (6)b 21 (2)b 10 206 (8)b  
SCC 11 9 2 0 11  
ASC 2 2 0 2  
LCLC 9 (1) b 9 (1) b 0 9 (1) b  
Adenocarcinoma subtypes (predominant pattern)c        0.207a
Lepidic 17 17 2 15  
Acinar 105 105 4 101  
Papillary 33 33 3 30  
Micropapillary 16 16 2 14  
Solid 20 20 0 20  
Invasive mucinous adenocarcinoma 8 8 1 7  
Fetal 1 1   0 1  
TMN staged        0.175a
I 114 114 0 6 108  
II 30 29 1 1 29  
III 55(IIIb:10) 53 2 0 55  
IV 38 18 20 3 35  
Sica gradinge        0.871a
Score 2 6 6 - 0 6  
Score 3 48 48 - 3 45  
Score 4 48 48 - 1 47  
Score 5 69 69 - 4 65  
Score 6 10 10 - 0 10  
WHO gradinge        0.597a
Low grade 17 17 - 1 16  
Intermediate grade 126 126 - 5 121  
High grade 38 38 - 2 36  
Another gene status       
ALK 228 (12)f 206 (11)f 22 (1)f 0 228  
EGFR 163 (87)f 141 (78)f 22 (9)f 0 163  
exon 19 deletion 37 33 4 0 37  
L858R 48g 44g 4 0 48  
L861Q 1 1 0 0 1  
exon 20 S768I 2g 1g 1 0 2  
KRAS 153 (13)f 136 (11)f 17 (2)f 0 153  
Gly12Asp 3 3 0 0 3  
Gly12Cys 4 4 0 0 4  
Gly12Val 4 4 0 0 4  
Gly12Ala 1 0 1 0 1  
Gly12Ser 1 0 1 0 1  
  1. Abbreviations: ADC Adenocarcinoma, SCC Squamous cell carcinoma, ASC Adenosquamous carcinoma, LCLC Large–cell lung carcinoma, ALK anaplastic lymphoma receptor tyrosine kinase, EGFR epidermal growth factor receptor, KRAS Kirsten rat sarcoma viral oncogene homolog
  2. aFisher exact test
  3. bMetastasis cases
  4. cTotal 190 resected adenocarcinoma with 200 predominant patterns were discussed. Some cases were including more than one predominant patterns
  5. dA case was diagnosed as stage 0
  6. eTotal 181 resected adenocarcinoma have been analyzed, excluding variant subtypes
  7. fThe cases with ALK rearrangement, EGFR mutation or KRAS mutation
  8. gThere was a case harboring both exon 21 L858R and exon 20 S768I mutation