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Table 4 Univariate and multivariate regression models of pre-operative factors predicting FFbF in men undergoing radical prostatectomy at University of Pennsylvania, 1990–2012

From: The impact of body mass index on treatment outcomes for patients with low-intermediate risk prostate cancer

Univariate analysis

HR

95 % CI

p value

Age

1

0.98 to 1.03

0.80

Racea

   

White

1

Reference

 

African-American/Black

1.28

0.92 to 1.78

0.15

 Serum PSA

1.03

1.02 to 1.04

<0.001

Clinical stagea

   

T1c

1

Reference

 

T2a

1.57

1.01 to 2.45

0.04

T2b

2.70

1.24 to 5.88

0.01

   > T2c

0.72

0.18 to 2.92

0.64

 Year of Prostatectomy

1.01

0.98 to 1.05

0.55

Clinical Gleason scorea

   

   ≤ 6

1

Reference

 

7

2.34

1.61 to 3.39

<0.001

   ≥ 8

4.63

3.12 to 6.87

<0.001

Body mass index, categoricala

   

   < 25 kg/m2

1

Reference

 

25 kg/m2 to <30 kg/m2

1.99

1.13 to 3.50

0.02

   ≥ 30 kg/m2

2.89

1.62 to 5.16

<0.001

Multivariate analysis

 Age

0.99

0.96 to 1.01

0.31

Racea

   

White

1

Reference

 

African-American/Black

0.67

0.43 to 1.04

0.07

 Serum PSA

1.02

1.01 to 1.03

<0.001

Clinical stagea

   

T1c

1

Reference

 

T2a

1.75

1.11 to 2.75

0.015

T2b

0.91

0.36 to 2.30

0.84

   > T2c

0.27

0.06 to 1.14

0.07

 Year of Prostatectomy

1.02

0.99 to 1.06

0.20

Clinical Gleason scorea

   

   ≤ 6

1

Reference

 

7

2.69

1.71 to 4.24

<0.001

   ≥ 8

7.27

4.26 to 12.42

<0.001

Body mass index, categoricala

   

   < 25 kg/m 2

1

Reference

 

25 kg/m 2 to <30 kg/m 2

1.97

0.97 to 4.01

0.06

   ≥ 30 kg/m 2

2.56

1.24 to 5.29

0.01

  1. Abbreviations: PSA prostate-specific antigen, FFbF freedom from biochemical failure
  2. aDenotes categorical variables. Body mass index, categorical uses BMI <25 kg/m2 as reference
  3. Race use White as reference category; “Other” race was dropped from model due to small numbers. Clinical stage, categorical uses (T1; T2a, T2b; >T2c), with T1c as reference category
  4. Clinical Gleason score, categorical (6, 7, ≥8); with 6 as reference category
  5. P values derived from a logistic regression model
  6. Boldfaced values represent statistically significance