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Table 4 Univariate and multivariate regression models of pre-operative factors predicting FFbF in men undergoing radical prostatectomy at University of Pennsylvania, 1990–2012

From: The impact of body mass index on treatment outcomes for patients with low-intermediate risk prostate cancer

Univariate analysis HR 95 % CI p value
Age 1 0.98 to 1.03 0.80
Racea    
White 1 Reference  
African-American/Black 1.28 0.92 to 1.78 0.15
 Serum PSA 1.03 1.02 to 1.04 <0.001
Clinical stagea    
T1c 1 Reference  
T2a 1.57 1.01 to 2.45 0.04
T2b 2.70 1.24 to 5.88 0.01
   > T2c 0.72 0.18 to 2.92 0.64
 Year of Prostatectomy 1.01 0.98 to 1.05 0.55
Clinical Gleason scorea    
   ≤ 6 1 Reference  
7 2.34 1.61 to 3.39 <0.001
   ≥ 8 4.63 3.12 to 6.87 <0.001
Body mass index, categoricala    
   < 25 kg/m2 1 Reference  
25 kg/m2 to <30 kg/m2 1.99 1.13 to 3.50 0.02
   ≥ 30 kg/m2 2.89 1.62 to 5.16 <0.001
Multivariate analysis
 Age 0.99 0.96 to 1.01 0.31
Racea    
White 1 Reference  
African-American/Black 0.67 0.43 to 1.04 0.07
 Serum PSA 1.02 1.01 to 1.03 <0.001
Clinical stagea    
T1c 1 Reference  
T2a 1.75 1.11 to 2.75 0.015
T2b 0.91 0.36 to 2.30 0.84
   > T2c 0.27 0.06 to 1.14 0.07
 Year of Prostatectomy 1.02 0.99 to 1.06 0.20
Clinical Gleason scorea    
   ≤ 6 1 Reference  
7 2.69 1.71 to 4.24 <0.001
   ≥ 8 7.27 4.26 to 12.42 <0.001
Body mass index, categoricala    
   < 25 kg/m 2 1 Reference  
25 kg/m 2 to <30 kg/m 2 1.97 0.97 to 4.01 0.06
   ≥ 30 kg/m 2 2.56 1.24 to 5.29 0.01
  1. Abbreviations: PSA prostate-specific antigen, FFbF freedom from biochemical failure
  2. aDenotes categorical variables. Body mass index, categorical uses BMI <25 kg/m2 as reference
  3. Race use White as reference category; “Other” race was dropped from model due to small numbers. Clinical stage, categorical uses (T1; T2a, T2b; >T2c), with T1c as reference category
  4. Clinical Gleason score, categorical (6, 7, ≥8); with 6 as reference category
  5. P values derived from a logistic regression model
  6. Boldfaced values represent statistically significance