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Fig. 3 | BMC Cancer

Fig. 3

From: PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma

Fig. 3

Growth of VM-CUB-3 cells with and without PIK3CA knockdown as xenografts. a. Immunoblot showing p110α protein expression in cells transduced with shRNA targeting PIK3CA (p110 KD) and non-specific control (control). b. 1 × 107 PIK3CA knockdown cells and controls cells were injected into 2 sites each in 4 mice. Tumor volumes are shown in mm3. Difference in volumes of p110 KD and control tumors were statistically significant at 42 days of growth (Student t test, with using Bonferroni’s correction for multiple testing; P < 0.017) and overall after 43 days of growth (Mann-Whitney test, P < 0.05). c. Bar chart illustrates the percentage of Ki67 stained cells counted in 5 areas of each tumor section. * indicates statistical significant difference (ANOVA test, P 0.05). Values represent mean ± S.E

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