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Fig. 5 | BMC Cancer

Fig. 5

From: Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis

Fig. 5

Changes in tumor apoptosis following different treatment regimens. a Formalin fixed liver sections with CRC liver metastases were stained for caspase 3 (apoptosis marker) First column Scale bar = 200 μm. Second column represents area within the inset of the first column at a higher magnification. Scale bar = 50 μm. b enumeration of apoptotic cells. Treatment groups vs control group (*P <0.003), Combination treated group vs OXi4503 treated (# P <0.006) and vs Sunitinib (# P <0.02. Data is expressed as mean value ± SEM, with n ≥ 5 for each group. Data was not normally distributed and non-parametric analysis was performed and statistical significance determined using Mann-Whitney U test

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