Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis

Table 7 Assessment of associations between proteins plasma membrane expression in CRC lymph node metastasis and pathological data

	MCT1		MCT4				CD147			GLUT1
	n	Positive (%)	p	n	Positive (%)	p	n	Positive (%)	p	n	Positive (%)	p
Tumor size (cm)
≤4.5	67	26 (38.8)	0.065	65	38 (58.5)	0.692	68	53 (92.5)	0.492^a	65	43 (76.7)	0.548^a
>4.5	45	10 (22.2)		45	28 (62.2)		45	40 (87.5)		40	25 (84.0)
Histological Type
Adenocarcinoma	92	32 (34.8)	0.287	92	54 (58.7)	0.376	90	76 (88.2)	0.826^a	85	58 (77.6)	0.084^a
A. Mucinous	16	2 (12.5)		15	7 (46.7)		18	14 (85.7)		17	6 (100.0)
A. Invasive	6	1 (16.7)		6	5 (83.3)		6	5 (100.0)		6	4 (100.0)
Signet ring and mucinous	3	1 (33.3)		1	1 (100.0)		3	1 (100.0)		1	1 (0.0)
Differentiation
Well-differentiated	41	18 (43.9)	0.152	40	23 (57.5)	0.493	41	36 (91.7)	0.033^a	38	26 (76.9)	0.902^a
Moderately-differentiated	51	13 (25.5)		50	28 (56.0)		50	43 (86.0)		47	29 (79.3)
Poorly-differentiated	23	5 (21.7)		22	15 (68.2)		23	16 (93.8)		22	13 (84.6)
Undifferentiated	1	0 (0.0)		1	0 (0.0)		2	1 (0.0)		1	1 (100.0)
Tumour Penetration
T1	2	0 (0.0)	0.408	1	0 (0.0)	0.034	2	1 (100.0)	0.665^a	1	1 (100.0)	0.653^a
T2	5	2 (40.0)		4	3 (75.0)		4	3 (100.0)		4	3 (66.7)
T3	101	22 (32.7)		99	62 (62.6)		101	83 (89.2)		96	61 (78.7)
T4	9	1 (11.1)		10	2 (20.0)		10	9 (77.8)		8	4 (100.0)
Spread to lymph nodes
Absent	9	4 (44.4)	0.450^a	8	6 (75.0)	0.465^a	10	8 (87.5)	1.000^a	8	6 (100.0)	0.326^a
Present	96	28 (29.2)		94	54 (57.4)		96	77 (89.6)		90	55 (76.4)
Vessel invasion
Absent	30	12 (40.0)	0.259	29	20 (69.0)	0.288	33	28 (89.3)	1.000^a	30	16 (81.3)	1.000^a
Present	80	23 (28.8)		78	45 (57.7)		79	62 (88.7)		73	49 (81.6)
TNM
Stage III	84	28 (33.3)	0.338	82	52 (63.4)	0.107	82	66 (92.4)	0.076	79	48 (81.3)	0.632
Stage IV	33	8 (24.2)		32	15 (46.9)		35	30 (80.0)		30	21 (76.2)

^aComparisons were examined for statistical significance using Fisher’s exact test (when n < 5)

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