Skip to main content

Table 7 Assessment of associations between proteins plasma membrane expression in CRC lymph node metastasis and pathological data

From: Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis

  MCT1 MCT4 CD147 GLUT1
  n Positive (%) p n Positive (%) p n Positive (%) p n Positive (%) p
Tumor size (cm)
 ≤4.5 67 26 (38.8) 0.065 65 38 (58.5) 0.692 68 53 (92.5) 0.492a 65 43 (76.7) 0.548a
 >4.5 45 10 (22.2)   45 28 (62.2)   45 40 (87.5)   40 25 (84.0)  
Histological Type
 Adenocarcinoma 92 32 (34.8) 0.287 92 54 (58.7) 0.376 90 76 (88.2) 0.826a 85 58 (77.6) 0.084a
 A. Mucinous 16 2 (12.5)   15 7 (46.7)   18 14 (85.7)   17 6 (100.0)  
 A. Invasive 6 1 (16.7)   6 5 (83.3)   6 5 (100.0)   6 4 (100.0)  
 Signet ring and mucinous 3 1 (33.3)   1 1 (100.0)   3 1 (100.0)   1 1 (0.0)  
Differentiation
 Well-differentiated 41 18 (43.9) 0.152 40 23 (57.5) 0.493 41 36 (91.7) 0.033a 38 26 (76.9) 0.902a
 Moderately-differentiated 51 13 (25.5)   50 28 (56.0)   50 43 (86.0)   47 29 (79.3)  
 Poorly-differentiated 23 5 (21.7)   22 15 (68.2)   23 16 (93.8)   22 13 (84.6)  
 Undifferentiated 1 0 (0.0)   1 0 (0.0)   2 1 (0.0)   1 1 (100.0)  
Tumour Penetration
 T1 2 0 (0.0) 0.408 1 0 (0.0) 0.034 2 1 (100.0) 0.665a 1 1 (100.0) 0.653a
 T2 5 2 (40.0)   4 3 (75.0)   4 3 (100.0)   4 3 (66.7)  
 T3 101 22 (32.7)   99 62 (62.6)   101 83 (89.2)   96 61 (78.7)  
 T4 9 1 (11.1)   10 2 (20.0)   10 9 (77.8)   8 4 (100.0)  
Spread to lymph nodes
 Absent 9 4 (44.4) 0.450a 8 6 (75.0) 0.465a 10 8 (87.5) 1.000a 8 6 (100.0) 0.326a
 Present 96 28 (29.2)   94 54 (57.4)   96 77 (89.6)   90 55 (76.4)  
Vessel invasion
 Absent 30 12 (40.0) 0.259 29 20 (69.0) 0.288 33 28 (89.3) 1.000a 30 16 (81.3) 1.000a
 Present 80 23 (28.8)   78 45 (57.7)   79 62 (88.7)   73 49 (81.6)  
TNM
 Stage III 84 28 (33.3) 0.338 82 52 (63.4) 0.107 82 66 (92.4) 0.076 79 48 (81.3) 0.632
 Stage IV 33 8 (24.2)   32 15 (46.9)   35 30 (80.0)   30 21 (76.2)  
  1. aComparisons were examined for statistical significance using Fisher’s exact test (when n < 5)