Table 2 Diagnostic outcomes. Assessments and instruments used in the POSITIVE study (Part III)

• Physical well being

Functional Assessment for Cancer Therapy – Lung

x

x

x

x

x

• General fatigue

Multidimensional Fatigue Inventory

x

x

x

x

x

• Physical performance (muscle strength and endurance capacity)

Spirometry, Six-Minute Walk Test, hand-held dynamometry, exercise log

x

x

x

x

x

• Psychosocial parameters (depression, anxiety, demoralization)

Ultra-Brief Patient Health Questionnaire (PHQ-4), Demoralization Scale, locus of control, Mini Nutrition Assessment

x

x

x

x

x

• Immunological parameters (cellular immunity, cytokine and chemokine panels in T-lymphocyte subsets)

Quantification of immune cell populations and tumor antigen reactive effector (memory T cells), detection of tumor reactive regulatory T cells, quantification of key immune effector molecules in serum.

x

x

x

• Care management phone calls

Edmonton Symptom Assessment Scale