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Table 2 Diagnostic outcomes. Assessments and instruments used in the POSITIVE study (Part III)

From: POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment

OutcomesInstrumentT0T1T2T3T4
Primary endpoints
• Physical well beingFunctional Assessment for Cancer Therapy – Lungxxxxx
• General fatigueMultidimensional Fatigue Inventoryxxxxx
Secondary endpoints
• Physical performance (muscle strength and endurance capacity)Spirometry, Six-Minute Walk Test, hand-held dynamometry, exercise logxxxxx
• Psychosocial parameters (depression, anxiety, demoralization)Ultra-Brief Patient Health Questionnaire (PHQ-4), Demoralization Scale, locus of control, Mini Nutrition Assessmentxxxxx
• Immunological parameters (cellular immunity, cytokine and chemokine panels in T-lymphocyte subsets)Quantification of immune cell populations and tumor antigen reactive effector (memory T cells), detection of tumor reactive regulatory T cells, quantification of key immune effector molecules in serum.xxx  
Others
• Care management phone callsEdmonton Symptom Assessment Scaleweekly
  1. Abbreviations: T0: Baseline; T1: 12 weeks after randomization; T2: 24 weeks after randomization; T3: 1st follow-up at week 40 after randomization; T4: 2nd follow-up at week 52 after randomization